Efficient methods for the synthesis of 1,3,7-triazaspiro[4.4]nonane-2,4-dione derivatives possessing an unsaturated pyrrolidine cycle have been developed affording intermediates and target compounds in high yields not requiring additional purification. Antimicrobial activity of the synthesized compounds was studied.
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The authors are indebted to the head of Laboratory of biochemistry of microorganisms and culture media of I. I. Mechnikov Institute of Microbiology and Immunology of the Academy of Medical Sciences of Ukraine (Kharkov), Candidate of biological sciences, senior researcher Tatyana Pavlovna Osolodchenko for carrying out the antimicrobial activity studies of the synthesized compounds.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2015, 51(5), 472–477
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Krolenko, K.Y., Silin, O.V., Vlasov, S.V. et al. An Efficient Synthesis of 1,3,7-Triazaspiro[4.4]Nonane-2,4-Dione Derivatives and Antimicrobial Activity Thereof. Chem Heterocycl Comp 51, 472–477 (2015). https://doi.org/10.1007/s10593-015-1721-6
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DOI: https://doi.org/10.1007/s10593-015-1721-6