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Synthesis and Evaluation of Reducing Capacity and Calcium Channel Blocking Activity of Novel 3,5-Dipropargylcarbonyl-Substituted 1,4-Dihydropyridines*

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Chemistry of Heterocyclic Compounds Aims and scope

Novel pyridinium salts based on 4-(3-pyridyl)-3,5-dipropargylcarbonyl-1,4-dihydropyridine were obtained by quaternization of pyridine moiety with different alkyl halides. The reducing capacity of the synthesized compounds was evaluated using the phosphomolybdenum complex method. The obtained results confirmed that all tested compounds possessed reducing capacity. Ca2+ channel antagonist and agonist activities of the compounds were additionaly assayed by changes in intracellular Ca2+ ion concentration in H9C2 and A7R5 cell lines. The obtained data confirmed that all synthesized 1,4-dihydropyridine derivatives have smooth muscle selective antagonist activities, and in the case of 4-phenyl derivative the activity was 4.7 times higher than that of amlodipine.

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This research work was supported by the European Social Fund Project No. ESF 2013/0002/1DP/1.1.1.2.0/13/APIA/VIAA/005 and the European Social Fund within the project “Support for Doctoral Studies at University of Latvia” (for Martins Rucins).

We are also grateful to Dr. Ilga Mutule for assistance in the work with MW equipment and B.Sc. Katrina Veinberga for technical assistance.

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Authors and Affiliations

  1. Latvian Institute of Organic Synthesis, 21 Aizkraukles St., Riga, LV-1006, Latvia

    M. Rucins, M. Gosteva, I. Domracheva, I. Kanepe-Lapsa, S. Belyakov, M. Plotniece, K. Pajuste, B. Cekavicus, A. Sobolev, I. Shestakova & А. Plotniece

  2. Faculty of Medicine, University of Latvia, 19 Raina Blvd., Riga, LV-1586, Latvia

    M. Rucins & M. Jekabsone

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  1. M. Rucins
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  2. M. Gosteva
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  6. M. Plotniece
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  11. I. Shestakova
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Correspondence to А. Plotniece.

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*Dedicated to Academician Professor G. Duburs on the occasion of his 80th birthday.

Published in Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1557-1568, October, 2014.

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Rucins, M., Gosteva, M., Domracheva, I. et al. Synthesis and Evaluation of Reducing Capacity and Calcium Channel Blocking Activity of Novel 3,5-Dipropargylcarbonyl-Substituted 1,4-Dihydropyridines*. Chem Heterocycl Comp 50, 1432–1443 (2015). https://doi.org/10.1007/s10593-014-1607-z

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