Abstract
As the final product of glycolysis, lactate features not only as an energy substrate, a metabolite, and a signaling molecule in a variety of diseases—such as cancer, inflammation, and sepsis—but also as a regulator of protein lactylation; this is a newly proposed epigenetic modification that is considered to be crucial for energy metabolism and signaling in brain tissues under both physiological and pathological conditions. In this review, evidence on lactylation from studies on lactate metabolism and disease has been summarized, revealing the function of lactate and its receptors in the regulation of brain function and summarizing the levels of lactylation expression in various brain diseases. Finally, the function of lactate and lactylation in the brain and the potential mechanisms of intervention in brain diseases are presented and discussed, providing optimal perspectives for future research on the role of lactylation in the brain.
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The figures from this article were created with BioRender.com. We are indebted to all individuals who participated in or helped with this research project.
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This study was supported by funding from the National Nature Science Foundation of China (Grant No.82174261, No.81673865, and No.81503669), Heilongiiang Natural Science Foundation (LH2021H084 and H2015031), the outstanding Training Foundation of Heilongjiang University of Chinese Medicine (2019JC05), the outstanding Innovative Talents Support Plan of Heilongjiang University of Chinese Medicine (2018RCD11).
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RL and YY are first authors, and contributed equally to this paper. RL and YY wrote the main manuscript text, HW, TZ, FD and KW prepared Figs. 1 and 2. SY and KX prepared Table 1. XJ and XS conceptualized the article and revised the final version. All authors read and approved the final manuscript.
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Li, R., Yang, Y., Wang, H. et al. Lactate and Lactylation in the Brain: Current Progress and Perspectives. Cell Mol Neurobiol 43, 2541–2555 (2023). https://doi.org/10.1007/s10571-023-01335-7
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DOI: https://doi.org/10.1007/s10571-023-01335-7