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Wnt3a/YTHDF1 Regulated Oxaliplatin-Induced Neuropathic Pain Via TNF-α/IL-18 Expression in the Spinal Cord

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Abstract

Oxaliplatin is widely used in cancer treatment, however, many patients will suffer from neuropathic pain (NP) induced by it at the same time. Therefore exploring the mechanism and founding novel target for this problem are needed. In this study, YTHDF1 showed upregulation in oxaliplatin treated mice. As m6A is known as conserved and it widely functions in numerous physiological and pathological processes. Therefore, we focused on exploring the molecular mechanism of whether and how YTHDF1 functions in NP induced by oxaliplatin. IHC and western blotting were conducted to measure proteins. Intrathecal injection for corresponding siRNAs in C57/BL6 mice or spinal microinjection for virus in YTHDF1flox/flox mice were applied to specially knockdown the expression of molecular. Von Frey, acetone test and ethyl chloride (EC) test were applied to evaluate NP behavior. YTHDF1, Wnt3a, TNF-α and IL-18 were increased in oxaliplatin treated mice, restricted the molecular mentioned above respectively can significantly attenuate oxaliplatin-induced NP, including the mechanical allodynia and cold allodynia. Silencing YTHDF1 and inhibiting Wnt3a and Wnt signaling pathways can reduce the enhancement of TNF-α and IL-18, and the decreasing of the upregulation of YTHDF1 can be found when inhibiting Wnt3a and Wnts signaling pathways in oxaliplatin treated mice. Our study indicated a novel pathway that can contribute to oxaliplatin-induced NP, the Wnt3a/YTHDF1 to cytokine pathway, which upregulating YTHDF1 functioned as the downstream of Wnt3a signal and promoted the translation of TNF-α and IL-18 in oxaliplatin treated mice.

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All data generated in this study are included in this manuscript.

Abbreviations

CCI:

Chronic constriction injury

CRC:

Colorectal cancer

CSF1:

Colony-stimulating factor 1

DMSO:

Dimethyl sulfoxide

DRG:

Dorsal root ganglion

EC:

Ethyl chloride

FTO:

Fat mass and obesity-associated protein

GFAP:

Glial fibrillary acidic protein

HCC:

Hepatocellular carcinoma

IHC:

Immunohistochemical

IL:

Interleukin

m6A:

N6-methyladenosine

METTL3:

Methyltransferase 3

NP:

Neuropathic pain

PH:

Pulmonary hypertension

PVDF:

Polyvinylidene fluoride

SiRNA:

Small interfering RNA

TNF:

Tumor necrosis factor

YTHDF:

YTH N6-methyladenosine RNA binding protein

References

  • Acevedo Rua L, Mumme M, Manferdini C, Darwiche S, Khalil A, Hilpert M, Buchner DA, Lisignoli G, Occhetta P, von Rechenberg B, Haug M, Schaefer DJ, Jakob M, Caplan A, Martin I, Barbero A, Pelttari K (2021) Engineered nasal cartilage for the repair of osteoarthritic knee cartilage defects. Sci Transl Med 13:eaaz1499

    Article  Google Scholar 

  • Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL (1994) Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 53:55–63

    Article  CAS  PubMed  Google Scholar 

  • Chen B, Dodge ME, Tang W, Lu J, Ma Z, Fan CW, Wei S, Hao W, Kilgore J, Williams NS, Roth MG, Amatruda JF, Chen C, Lum L (2009) Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol 5:100–107

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ciani L, Salinas PC (2005) WNTs in the vertebrate nervous system: from patterning to neuronal connectivity. Nat Rev Neurosci 6:351–362

    Article  CAS  PubMed  Google Scholar 

  • Clevers H, Nusse R (2012) Wnt/beta-catenin signaling and disease. Cell 149:1192–1205

    Article  CAS  PubMed  Google Scholar 

  • Cohen R, Taieb J, Fiskum J, Yothers G, Goldberg R, Yoshino T, Alberts S, Allegra C, de Gramont A, Seitz JF, O’Connell M, Haller D, Wolmark N, Erlichman C, Zaniboni A, Lonardi S, Kerr R, Grothey A, Sinicrope FA, Andre T, Shi Q (2021) Microsatellite instability in patients with stage III colon cancer receiving fluoropyrimidine with or without oxaliplatin: an ACCENT pooled analysis of 12 adjuvant trials. J Clin Oncol 39:642–651

    Article  CAS  PubMed  Google Scholar 

  • Dominissini D, Moshitch-Moshkovitz S, Schwartz S, Salmon-Divon M, Ungar L, Osenberg S, Cesarkas K, Jacob-Hirsch J, Amariglio N, Kupiec M, Sorek R, Rechavi G (2012) Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature 485:201–206

    Article  CAS  PubMed  Google Scholar 

  • Gong Q, Lin Y, Lu Z, Xiao Z (2020) Microglia-astrocyte cross talk through IL-18/IL-18R signaling modulates migraine-like behavior in experimental models of migraine. Neuroscience 451:207–215

    Article  CAS  PubMed  Google Scholar 

  • Guan Z, Kuhn JA, Wang X, Colquitt B, Solorzano C, Vaman S, Guan AK, Evans-Reinsch Z, Braz J, Devor M, Abboud-Werner SL, Lanier LL, Lomvardas S, Basbaum AI (2016) Injured sensory neuron-derived CSF1 induces microglial proliferation and DAP12-dependent pain. Nat Neurosci 19:94–101

    Article  CAS  PubMed  Google Scholar 

  • Han CH, Kilfoyle DH, Hill AG, Jameson MB, McKeage MJ (2016) Preventing oxaliplatin-induced neurotoxicity: rationale and design of phase Ib randomized, double-blind, placebo-controlled, cross-over trials for early clinical evaluation of investigational therapeutics. Expert Opin Drug Metab Toxicol 12:1479–1490

    Article  CAS  PubMed  Google Scholar 

  • Han D, Liu J, Chen C, Dong L, Liu Y, Chang R, Huang X, Liu Y, Wang J, Dougherty U, Bissonnette MB, Shen B, Weichselbaum RR, Xu MM, He C (2019) Anti-tumour immunity controlled through mRNA m(6)A methylation and YTHDF1 in dendritic cells. Nature 566:270–274

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Han B, Yan S, Wei S, Xiang J, Liu K, Chen Z, Bai R, Sheng J, Xu Z, Gao X (2020) YTHDF1-mediated translation amplifies Wnt-driven intestinal stemness. EMBO Rep 21:e49229

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • He L, Li H, Wu A, Peng Y, Shu G, Yin G (2019) Functions of N6-methyladenosine and its role in cancer. Mol Cancer 18:176

    Article  PubMed  PubMed Central  Google Scholar 

  • Hu L, Wang J, Huang H, Yu Y, Ding J, Yu Y, Li K, Wei D, Ye Q, Wang F, Shen B, Chen J, Fulton DJR, Chen F (2021) YTHDF1 regulates pulmonary hypertension through translational control of MAGED1. Am J Respir Crit Care Med 203:1158–1172

    Article  CAS  PubMed  Google Scholar 

  • Ji RR, Strichartz G (2004) Cell signaling and the genesis of neuropathic pain. Sci STKE 2004:reE14

    Article  PubMed  Google Scholar 

  • Jiang X, Liu B, Nie Z, Duan L, Xiong Q, Jin Z, Yang C, Chen Y (2021) The role of m6A modification in the biological functions and diseases. Signal Transduct Target Ther 6:74

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kawasaki Y, Xu ZZ, Wang X, Park JY, Zhuang ZY, Tan PH, Gao YJ, Roy K, Corfas G, Lo EH, Ji RR (2008) Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain. Nat Med 14:331–336

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kidwell KM, Yothers G, Ganz PA, Land SR, Ko CY, Cecchini RS, Kopec JA, Wolmark N (2012) Long-term neurotoxicity effects of oxaliplatin added to fluorouracil and leucovorin as adjuvant therapy for colon cancer: results from National Surgical Adjuvant Breast and Bowel Project trials C-07 and LTS-01. Cancer 118:5614–5622

    Article  CAS  PubMed  Google Scholar 

  • Koistinaho M, Koistinaho J (2002) Role of p38 and p44/42 mitogen-activated protein kinases in microglia. Glia 40:175–183

    Article  PubMed  Google Scholar 

  • Kwiatkowski K, Pawlik K, Ciapala K, Piotrowska A, Makuch W, Mika J (2020) Bidirectional action of cenicriviroc, a CCR2/CCR5 antagonist, results in alleviation of pain-related behaviors and potentiation of opioid analgesia in rats with peripheral neuropathy. Front Immunol 11:615327

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Leonard GD, Wright MA, Quinn MG, Fioravanti S, Harold N, Schuler B, Thomas RR, Grem JL (2005) Survey of oxaliplatin-associated neurotoxicity using an interview-based questionnaire in patients with metastatic colorectal cancer. BMC Cancer 5:116

    Article  PubMed  PubMed Central  Google Scholar 

  • Li Y, Xiao J, Bai J, Tian Y, Qu Y, Chen X, Wang Q, Li X, Zhang Y, Xu J (2019) Molecular characterization and clinical relevance of m(6)A regulators across 33 cancer types. Mol Cancer 18:137

    Article  PubMed  PubMed Central  Google Scholar 

  • Li Y, Guo X, Sun L, Xiao J, Su S, Du S, Li Z, Wu S, Liu W, Mo K, Xia S, Chang YJ, Denis D, Tao YX (2020) N(6)-Methyladenosine demethylase FTO contributes to neuropathic pain by stabilizing G9a expression in primary sensory neurons. Adv Sci (weinh) 7:1902402

    Article  CAS  PubMed  Google Scholar 

  • Liu N, Zhou KI, Parisien M, Dai Q, Diatchenko L, Pan T (2017) N6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein. Nucleic Acids Res 45:6051–6063

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Liu H, Li D, Sun L, Qin H, Fan A, Meng L, Graves-Deal R, Glass SE, Franklin JL, Liu Q, Wang J, Yeatman TJ, Guo H, Zong H, Jin S, Chen Z, Deng T, Fang Y, Li C, Karijolich J, Patton JG, Wang X, Nie Y, Fan D, Coffey RJ, Zhao X, Lu Y (2022a) Interaction of lncRNA MIR100HG with hnRNPA2B1 facilitates m(6)A-dependent stabilization of TCF7L2 mRNA and colorectal cancer progression. Mol Cancer 21:74

    Article  PubMed  PubMed Central  Google Scholar 

  • Liu XS, Kui XY, Gao Y, Chen XQ, Zeng J, Liu XY, Zhang Y, Zhang YH, Pei ZJ (2022b) Comprehensive analysis of YTHDF1 immune infiltrates and ceRNA in human esophageal carcinoma. Front Genet 13:835265

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Merkurjev D, Hong WT, Iida K, Oomoto I, Goldie BJ, Yamaguti H, Ohara T, Kawaguchi SY, Hirano T, Martin KC, Pellegrini M, Wang DO (2018) Synaptic N(6)-methyladenosine (m(6)A) epitranscriptome reveals functional partitioning of localized transcripts. Nat Neurosci 21:1004–1014

    Article  CAS  PubMed  Google Scholar 

  • Miaskowski C, Mastick J, Paul SM, Topp K, Smoot B, Abrams G, Chen LM, Kober KM, Conley YP, Chesney M, Bolla K, Mausisa G, Mazor M, Wong M, Schumacher M, Levine JD (2017) Chemotherapy-induced neuropathy in cancer survivors. J Pain Symptom Manage 54(204–18):e2

    Google Scholar 

  • Miyoshi K, Obata K, Kondo T, Okamura H, Noguchi K (2008) Interleukin-18-mediated microglia/astrocyte interaction in the spinal cord enhances neuropathic pain processing after nerve injury. J Neurosci 28:12775–12787

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nie B, Liu C, Bai X, Chen X, Wu S, Zhang S, Huang Z, Xie M, Xu T, Xin W, Zeng W, Ouyang H (2018) AKAP150 involved in paclitaxel-induced neuropathic pain via inhibiting CN/NFAT2 pathway and downregulating IL-4. Brain Behav Immun 68:158–168

    Article  CAS  PubMed  Google Scholar 

  • Nusse R, Clevers H (2017) Wnt/beta-catenin signaling, disease, and emerging therapeutic modalities. Cell 169:985–999

    Article  CAS  PubMed  Google Scholar 

  • Osada T, Chen M, Yang XY, Spasojevic I, Vandeusen JB, Hsu D, Clary BM, Clay TM, Chen W, Morse MA, Lyerly HK (2011) Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations. Cancer Res 71:4172–4182

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pan Z, Zhang Q, Liu X, Zhou H, Jin T, Hao LY, Xie L, Zhang M, Yang XX, Sun ML, Xue ZY, Tao Y, Ye XC, Shen W, Cao JL (2021) Methyltransferase-like 3 contributes to inflammatory pain by targeting TET1 in YTHDF2-dependent manner. Pain 162:1960–1976

    Article  CAS  PubMed  Google Scholar 

  • Park SH, Lim DH, Sohn TS, Lee J, Zang DY, Kim ST, Kang JH, Oh SY, Hwang IG, Ji JH, Shin DB, Yu JI, Kim KM, An JY, Choi MG, Lee JH, Kim S, Hong JY, Park JO, Park YS, Lim HY, Bae JM, Kang WK, Artist investigators (2021) A randomized phase III trial comparing adjuvant single-agent S1, S-1 with oxaliplatin, and postoperative chemoradiation with S-1 and oxaliplatin in patients with node-positive gastric cancer after D2 resection: the ARTIST 2 trial(). Ann Oncol 32:368–374

    Article  CAS  PubMed  Google Scholar 

  • Pasetto LM, D’Andrea MR, Rossi E, Monfardini S (2006) Oxaliplatin-related neurotoxicity: how and why? Crit Rev Oncol Hematol 59:159–168

    Article  PubMed  Google Scholar 

  • Riccardi A, Ferlini C, Meco D, Mastrangelo R, Scambia G, Riccardi R (1999) Antitumour activity of oxaliplatin in neuroblastoma cell lines. Eur J Cancer 35:86–90

    Article  CAS  PubMed  Google Scholar 

  • Rong L, Xu Y, Zhang K, Jin L, Liu X (2022) HNRNPA2B1 inhibited SFRP2 and activated Wnt-beta/catenin via m6A-mediated miR-106b-5p processing to aggravate stemness in lung adenocarcinoma. Pathol Res Pract 233:153794

    Article  CAS  PubMed  Google Scholar 

  • Shi H, Zhang X, Weng YL, Lu Z, Liu Y, Lu Z, Li J, Hao P, Zhang Y, Zhang F, Wu Y, Delgado JY, Su Y, Patel MJ, Cao X, Shen B, Huang X, Ming GL, Zhuang X, Song H, He C, Zhou T (2018) m(6)A facilitates hippocampus-dependent learning and memory through YTHDF1. Nature 563:249–253

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sisignano M, Baron R, Scholich K, Geisslinger G (2014) Mechanism-based treatment for chemotherapy-induced peripheral neuropathic pain. Nat Rev Neurol 10:694–707

    Article  CAS  PubMed  Google Scholar 

  • Wang X, Zhao BS, Roundtree IA, Lu Z, Han D, Ma H, Weng X, Chen K, Shi H, He C (2015) N(6)-methyladenosine modulates messenger RNA translation efficiency. Cell 161:1388–1399

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang S, Gao S, Zeng Y, Zhu L, Mo Y, Wong CC, Bao Y, Su P, Zhai J, Wang L, Soares F, Xu X, Chen H, Hezaveh K, Ci X, He A, McGaha T, O’Brien C, Rottapel R, Kang W, Wu J, Zheng G, Cai Z, Yu J, He HH (2022) N6-Methyladenosine reader YTHDF1 promotes ARHGEF2 translation and RhoA signaling in colorectal cancer. Gastroenterology 162:1183–1196

    Article  CAS  PubMed  Google Scholar 

  • Watkins LR, Maier SF (2002) Beyond neurons: evidence that immune and glial cells contribute to pathological pain states. Physiol Rev 82:981–1011

    Article  CAS  PubMed  Google Scholar 

  • Watkins LR, Maier SF (2003) Glia: a novel drug discovery target for clinical pain. Nat Rev Drug Discov 2:973–985

    Article  CAS  PubMed  Google Scholar 

  • Watkins LR, Hutchinson MR, Milligan ED, Maier SF (2007) “Listening” and “talking” to neurons: implications of immune activation for pain control and increasing the efficacy of opioids. Brain Res Rev 56:148–169

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Weng YL, Wang X, An R, Cassin J, Vissers C, Liu Y, Liu Y, Xu T, Wang X, Wong SZH, Joseph J, Dore LC, Dong Q, Zheng W, Jin P, Wu H, Shen B, Zhuang X, He C, Liu K, Song H, Ming GL (2018) Epitranscriptomic m(6)A regulation of axon regeneration in the adult mammalian nervous system. Neuron 97(313–25):e6

    Google Scholar 

  • Wilson RH, Lehky T, Thomas RR, Quinn MG, Floeter MK, Grem JL (2002) Acute oxaliplatin-induced peripheral nerve hyperexcitability. J Clin Oncol 20:1767–1774

    Article  CAS  PubMed  Google Scholar 

  • Xie YK, Luo H, Zhang SX, Chen XY, Guo R, Qiu XY, Liu S, Wu H, Chen WB, Zhen XH, Ma Q, Tian JL, Li S, Chen X, Han Q, Duan S, Shen C, Yang F, Xu ZZ (2022) GPR177 in A-fiber sensory neurons drives diabetic neuropathic pain via WNT-mediated TRPV1 activation. Sci Transl Med 14:eabh2557

    Article  CAS  PubMed  Google Scholar 

  • Xiong Q, Liu C, Zheng X, Zhou X, Lei K, Zhang X, Wang Q, Lin W, Tong R, Xu R, Yuan Q (2022) METTL3-mediated m(6)A RNA methylation regulates dorsal lingual epithelium homeostasis. Int J Oral Sci 14:26

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yang Y, Zhao B, Gao X, Sun J, Ye J, Li J, Cao P (2021) Targeting strategies for oxaliplatin-induced peripheral neuropathy: clinical syndrome, molecular basis, and drug development. J Exp Clin Cancer Res 40:331

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhang YK, Huang ZJ, Liu S, Liu YP, Song AA, Song XJ (2013) WNT signaling underlies the pathogenesis of neuropathic pain in rodents. J Clin Invest 123:2268–2286

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhang L, Zhao X, Wang J, Jin Y, Gong M, Ye Y, Li P (2022) METTL3 suppresses neuropathic pain via modulating N6-methyladenosine-dependent primary miR-150 processing. Cell Death Discov 8:80

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhao Z, Meng J, Su R, Zhang J, Chen J, Ma X, Xia Q (2020) Epitranscriptomics in liver disease: basic concepts and therapeutic potential. J Hepatol 73:664–679

    Article  CAS  PubMed  Google Scholar 

  • Zhou Y, Yin Z, Hou B, Yu M, Chen R, Jin H, Jian Z (2019) Expression profiles and prognostic significance of RNA N6-methyladenosine-related genes in patients with hepatocellular carcinoma: evidence from independent datasets. Cancer Manag Res 11:3921–3931

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhou YQ, Tian XB, Tian YK, Mei W, Liu DQ, Ye DW (2022) Wnt signaling: a prospective therapeutic target for chronic pain. Pharmacol Ther 231:107984

    Article  CAS  PubMed  Google Scholar 

  • Zhuang M, Li X, Zhu J, Zhang J, Niu F, Liang F, Chen M, Li D, Han P, Ji SJ (2019) The m6A reader YTHDF1 regulates axon guidance through translational control of Robo3.1 expression. Nucleic Acids Res 47:4765–4777

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

We thank Pro. Ruihua Xu and Pro. Huaiqiang Ju from providing the YTHDF1flox/flox mice.

Funding

This work was supported by the National Natural Science Foundation of China (82071237 and 81771192) and H.O.’s Clinical Medical Scientists Project of Sun Yat-sen University Cancer Center (PT09090101).

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Author notes

  1. Xiaohui Bai, Yongtian Huang and Wan Huang contributed equally to this work.

Authors and Affiliations

  1. Department of Anesthesiology, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yanjiang Road West, Guangzhou, China

    Xiaohui Bai, Kun Zhang & Yujuan Li

  2. Department of Anesthesiology, State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng Road East, Guangzhou, China

    Yongtian Huang, Wan Huang, Yingjun Zhang & Handong Ouyang

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  1. Xiaohui Bai
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Contributions

XB and HO conceptualized this study. XB, YH and. HO determined the methodology. XB, YH, WH and KZ performed the investigations. HO and YH wrote the original draft. HO, WH, YL, XB, YZ and YH wrote, reviewed, and edited the draft. Funding acquisition: HO acquired funding. HO provided resources. YL and HO supervised the overall study.

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Correspondence to Yujuan Li or Handong Ouyang.

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Bai, X., Huang, Y., Huang, W. et al. Wnt3a/YTHDF1 Regulated Oxaliplatin-Induced Neuropathic Pain Via TNF-α/IL-18 Expression in the Spinal Cord. Cell Mol Neurobiol 43, 1583–1594 (2023). https://doi.org/10.1007/s10571-022-01267-8

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