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Therapeutic Potential of Berberine in the Treatment of Glioma: Insights into Its Regulatory Mechanisms

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Abstract

Glioma is known as one of the most common primary intracranial tumors accounting for four-fifths of malignant brain tumors. There are several biological pathways that play a synergistic, pathophysiological role in glioma, including apoptosis, autophagy, oxidative stress, and cell cycle arrest. According to previous rese arches, the drugs used in the treatment of glioma have been associated with significant limitations. Therefore, improved and/or new therapeutic platforms are required. In this regard, multiple flavonoids and alkaloids have been extensively studied in the treatment of glioma. Berberine is a protoberberine alkaloid with wide range of pharmacological activities, applicable to various pathological conditions. Few studies have reported beneficial roles of berberine in glioma. Berberine exerts its pharmacological functions in glioma by controlling different molecular and cellular pathways. We reviewed the existing knowledge supporting the use of berberine in the treatment of glioma and its effects on molecular and cellular mechanisms.

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Authors and Affiliations

  1. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran

    Zatollah Asemi, Hamed Mirzaei & Omid Reza Tamtaji

  2. Halal Research Center of IRI, FDA, Tehran, Iran

    Mohammad Behnam

  3. Department of Radiobiology, Iran University of Medical Sciences, Tehran, Islamic Republic of Iran

    Mohammad Ali Pourattar

  4. Student Research Committee, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran

    Zahra Sadat Razavi

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  1. Zatollah Asemi
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  2. Mohammad Behnam
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ZA, MB, M-AP, HM, and Z-SR and O-RT contributed in the conception or design of the work and drafting of the manuscript. All authors confirmed the final version for submission.

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Asemi, Z., Behnam, M., Pourattar, M.A. et al. Therapeutic Potential of Berberine in the Treatment of Glioma: Insights into Its Regulatory Mechanisms. Cell Mol Neurobiol 41, 1195–1201 (2021). https://doi.org/10.1007/s10571-020-00903-5

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