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Smart cellulose-derived magnetic hydrogel with rapid swelling and deswelling properties for remotely controlled drug release

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Abstract

Although cellulose hydrogels are one of promising biomaterials for drug release carrier, their passive manner of drug release and the absence of remote stimuli response limit their further applications. Herein, we report a simple one-pot method for the synthesis of magnetic β-cyclodextrin (β-CD)/cellulose hydrogel beads, which exhibited rapid swelling–deswelling properties under an external magnetic field (EMF) to remotely control drug release from passive release to stepwise release. The grafted β-CD endows the hydrogel with high drug loading capacity and, simultaneously, the incorporation of Fe3O4 nanoparticles provide the force for stepwise drug release through EMF induced rapid and reversible deformation of 3D network. We demonstrate that the efficiency of the hydrogel in the stepwise drug release dose and rate can be controlled by switching on–off the EMF and adjusting the content of Fe3O4 nanoparticles. Additionally, results from cytotoxicity tests confirmed the excellent biocompatibility of the developed hydrogel, which is promising to be used in the biomedical field.

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Acknowledgments

We acknowledge the generous financial support of the Special Scientific Research Fund for Public Service Sectors of Forestry (No. 201504603), Science Foundation for Distinguished Young Scholars of Fujian Agriculture and Forestry University (No. xjq201503), Scientific Research Foundation of Graduate School of Fujian Agriculture and Forestry University (No. 324-1122yb041). B. Lu also thanks the support of the outstanding youth scientific research personnel training plan of colleges and universities in Fujian Province.

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Authors and Affiliations

  1. College of Material Engineering, Fujian Agriculture and Forestry University, Minhou County, Fuzhou, Fujian, China

    Fengcai Lin, Junjian Zheng, Weihong Guo, Zhiting Zhu, Zi Wang, Biao Huang & Beili Lu

  2. Fujian Key Laboratory of Developmental and Neural Biology, College of Life Sciences, Fujian Normal University, No.1 Science and Technology Road, Minhou County, Fuzhou, 350108, Fujian, China

    Biying Dong & Chensheng Lin

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  1. Fengcai Lin
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Lin, F., Zheng, J., Guo, W. et al. Smart cellulose-derived magnetic hydrogel with rapid swelling and deswelling properties for remotely controlled drug release. Cellulose 26, 6861–6877 (2019). https://doi.org/10.1007/s10570-019-02572-0

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