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Preparation and swelling behavior of pH/temperature responsive semi-IPN hydrogel based on carboxymethyl xylan and poly(N-isopropyl acrylamide)

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Abstract

In this study, carboxymethyl xylan was synthesized from wheat straw xylan and then pH/temperature dual-responsive hydrogels based on the carboxymethyl xylan (CMX) and poly(N-isopropylacrylamide) (PNIPAm) were firstly synthesized through semi-interpenetrating polymer network synthetic route. The temperature-responsive behavior was investigated by swelling experiment and DSC test, showing that the CMX content played an important role in the phase transition, and the CMX–PNIPAm hydrogel had higher pH sensitivity compared with PNIPAm hydrogel. The CMX content and the interconnected pore structure within the network improved the swelling, and the CMX–PNIPAm hydrogels had a high de-swelling rate. Addition of AAc in the hydrogels can improve pH sensitivity but decrease temperature sensitivity. The excellent swelling reversibility in response to temperature was verified through the oscillatory experiments of swelling and de-swelling. It is expected that the CMX–PNIPAm hydrogels could be used in biomedical fields as an intelligent material, especially for drug delivery.

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Abbreviations

BIS:

N-Methylene bisacrylamide

CMX:

Carboxymethyl xylan

13C-NMR:

C-Nuclear magnetic resonance

DSC:

Differential scanning calorimetry

FT-IR:

Fourier transform infrared spectroscopy

GC:

Gas chromatography

LCST:

Lower critical solution temperature

PNIPAm:

Poly(N-isopropylacrylamide)

SEM:

Scanning electron microscopy

semi-IPN:

Semi-interpenetrating polymer network

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Acknowledgments

The authors appreciate the supports by the National Natural Science Foundation of China (No. 20707016), Natural Science Basic Research Plan in Shaanxi Province of China (No. 2017JM2003), and the Seed Foundation of Innovation and Creation for Graduate Students in Northwestern Polytechnical University (No. Z2019204).

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Authors and Affiliations

  1. Department of Applied Chemistry, School of Science, Northwestern Polytechnic University, Xi’an, 710072, China

    Xiao-Feng Sun, Qihang Zeng, Haihong Wang & Yiwei Hao

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  1. Xiao-Feng Sun
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  2. Qihang Zeng
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  3. Haihong Wang
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  4. Yiwei Hao
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Correspondence to Xiao-Feng Sun.

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Sun, XF., Zeng, Q., Wang, H. et al. Preparation and swelling behavior of pH/temperature responsive semi-IPN hydrogel based on carboxymethyl xylan and poly(N-isopropyl acrylamide). Cellulose 26, 1909–1922 (2019). https://doi.org/10.1007/s10570-018-2180-x

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  • DOI: https://doi.org/10.1007/s10570-018-2180-x

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