Abstract
The recent study focusing on paper coated with microfibrillated cellulose (MFC) revealed the ability of such a structure to achieve a controlled release of molecules introduced into its nanoporous network. The present study examines this concept using a chlorhexidine digluconate-based (CHX) antibacterial solution. Various analyses were performed, optical microscopy, FE-SEM and AFM to underline the structure of the nanoporous MFC network. Release studies were conducted in an aqueous medium following two different protocols and antibacterial tests were done to evaluate the efficiency of the final materials obtained. MFC coating provided a slower and more progressive release of CHX. Indeed, papers impregnated with CHX were active for 18 days, whereas papers coated with CHX/MFC retained their antibacterial activity for 45 days. In parallel, similar tests were carried out using a model coating slurry, and although the rate of release of CHX was also slowed down, the quantities released were insufficient to confer any antibacterial activity. In conclusion, this study suggests that the use of MFC as a coating could be very promising since it allows a controlled and progressive release of molecules preserving long-term antibacterial activity.
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Acknowledgments
The authors would like to thank Sandra Tapin-Lingua (FCBA, France) for supplying the MFC suspension. This work was made possible by the use of specific equipment of the TekLiCell platform supported by Region Rhône-Alpes through FEDER (European fund for regional development) funding. LGP2 is part of the LabEx Tec 21 (Investissements d’Avenir - grant agreement n°ANR-11-LABX-0030) and of the Énergies du Futur and PolyNat Carnot Institutes (Investissements d’Avenir - grant agreements n°ANR-11-CARN-007-01 and ANR-11-CARN-030-01).
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Lavoine, N., Desloges, I., Sillard, C. et al. Controlled release and long-term antibacterial activity of chlorhexidine digluconate through the nanoporous network of microfibrillated cellulose. Cellulose 21, 4429–4442 (2014). https://doi.org/10.1007/s10570-014-0392-2
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DOI: https://doi.org/10.1007/s10570-014-0392-2