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Cu-MOF as Reusable Catalyst for the One-Pot Three-Component Synthesis of 2-Substituted Benzothiazoles Using 2-Iodoaniline, Aldehydes and Elemental Sulfur

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Abstract

A facile synthesis of various 2-substituted benzothiazoles has been developed by Cu-MOF as a recyclable heterogeneous catalyst in one-pot three-component reactions of 4-chloro-2-iodoaniline, aromatic and aliphatic aldehydes, and elemental sulfur in DMF at 110 °C with good yield. This reaction showed a good functional group tolerance to produce the corresponding 2-substituted benzothiazoles in good yields in the absence of any additive. The results showed that the catalyst can be recycled and reused for four times. The chemical structures of the all-synthesized compounds were confirmed by NMR and CHN analysis.

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  1. Department of Chemistry, Science and Research Branch, Islamic Azad University, P.O. Box 14515/775, Tehran, Iran

    Haniyeh Zandieh, Javad Mokhtari & Kambiz Larijani

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  1. Haniyeh Zandieh
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  2. Javad Mokhtari
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  3. Kambiz Larijani
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Zandieh, H., Mokhtari, J. & Larijani, K. Cu-MOF as Reusable Catalyst for the One-Pot Three-Component Synthesis of 2-Substituted Benzothiazoles Using 2-Iodoaniline, Aldehydes and Elemental Sulfur. Catal Lett 153, 3527–3533 (2023). https://doi.org/10.1007/s10562-022-04250-6

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