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β-Cyclodextrin as a Biomimetic Catalyst for the Efficient Synthesis of 4-Oxo-pyrido[1,2-a] Pyrimidine-3-Carbonitrile in Aqueous Medium

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Abstract

Supramolecular β-cyclodextrin as a highly efficient, biodegradable, and reusable catalyst for the synthesis of 4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbonitrile derivatives (4a–s) is investigated via a cascade reaction of aldehydes, malanonitrile and 2-aminopyridine in aqueous medium at 65 °C under ultrasonication. This procedure has the advantages of good yields, easy work-up, and benign environment friendly character. All of the synthesized derivatives were evaluated for their in vitro antibacterial activity against four bacterial strains.

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Acknowledgements

The authors are thankful to Professor Ramrao A. Mane for his invaluable discussions and guidance. The authors are also thankful to Central Drug Research Institute (CDRI), Lucknow for spectral analysis.

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Authors and Affiliations

  1. Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra, 431004, India

    Akash Ghorad, Sagar Mahalle, Lalit D. Khillare & Manisha R. Bhosle

  2. Department of Pharmaceutical Chemistry, Y. B. Chavan College of Pharmacy, Rafiq Zakaria Campus, Aurangabad, 431 001, India

    Jaiprakash N. Sangshetti

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  1. Akash Ghorad
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  2. Sagar Mahalle
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Correspondence to Manisha R. Bhosle.

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Ghorad, A., Mahalle, S., Khillare, L.D. et al. β-Cyclodextrin as a Biomimetic Catalyst for the Efficient Synthesis of 4-Oxo-pyrido[1,2-a] Pyrimidine-3-Carbonitrile in Aqueous Medium. Catal Lett 147, 640–648 (2017). https://doi.org/10.1007/s10562-017-1983-y

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