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Protective effects of mesenchymal stem cells on ischemic brain injury: therapeutic perspectives of regenerative medicine

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Abstract

Cerebral ischemic injury as the main manifestation of stroke can occur in stroke patients (70–80%). Nowadays, the main therapeutic strategy used for ischemic brain injury treatment aims to achieve reperfusion, neuroprotection, and neurorecovery. Also, angiogenesis as a therapeutic approach maybe represents a promising tool to enhance the prognosis of cerebral ischemic stroke. Unfortunately, although many therapeutic approaches as a life-saving gateway for cerebral ischemic injuries like pharmacotherapy and surgical treatments are widely used, they all fail to restore or regenerate damaged neurons in the brain. So, the suitable therapeutic approach would focus on regenerating the lost cells and restore the normal function of the brain. Currently, stem cell-based regenerative medicine introduced a new paradigm approach in cerebral ischemic injuries treatment. Today, in experimental researches, different types of stem cells such as mesenchymal stem cells have been applied. Therefore, stem cell-based regenerative medicine provides the opportunity to inquire and develop a more effective and safer therapeutic approach with the capability to produce and regenerate new neurons in damaged tissues.

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Acknowledgements

This work was supported by grants from the Vice Chancellor for Research and Technology, Kashan University of Medical Sciences, Kashan, Iran; and Shahid Beheshti University of Medical Sciences, Tehran, Iran; Saeid & Maryam.

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  1. Department of Physiology and Neurophysiology Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Saeid Bagheri-Mohammadi

  2. Department of Physiology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran

    Saeid Bagheri-Mohammadi

  3. Departments of Applied Cell Sciences, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran

    Saeid Bagheri-Mohammadi

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Bagheri-Mohammadi, S. Protective effects of mesenchymal stem cells on ischemic brain injury: therapeutic perspectives of regenerative medicine. Cell Tissue Bank 22, 249–262 (2021). https://doi.org/10.1007/s10561-020-09885-6

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