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Catalog of genetic progression of human cancers: non-Hodgkin lymphoma

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Abstract

The recent application of next-generation sequencing technologies lead to significant improvements in our understanding of genetic underpinnings of non-Hodgkin lymphomas with identification of an unexpectedly high number of novel mutation targets across the different B-cell lymphoma entities. These recently discovered molecular lesions are expected to have a major impact on development of novel biomarkers and targeted therapies as well as patient stratification based on the underlying genetic profile. This review will cover the major discoveries in B-cell lymphomas using next-generation sequencing technologies over the last few years, highlighting alterations associated with relapse and progression of these diseases.

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Acknowledgments

C.B. is funded by the Lendulet program of the Hungarian Academy of Sciences and OTKA-PD108805 grant. L.R. is supported by KTIA_NAP_13-2014-0021, OTKA-PD115792 and OTKA-K116151 grants.

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Authors and Affiliations

  1. MTA-SE Lendulet Molecular Oncohematology Research Group, Budapest, Hungary

    Csaba Bödör

  2. 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary

    Csaba Bödör & Lilla Reiniger

  3. 2nd Department of Pathology, MTA-SE NAP, Brain Metastasis Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary

    Lilla Reiniger

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  1. Csaba Bödör
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  2. Lilla Reiniger
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Correspondence to Lilla Reiniger.

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Bödör, C., Reiniger, L. Catalog of genetic progression of human cancers: non-Hodgkin lymphoma. Cancer Metastasis Rev 35, 109–127 (2016). https://doi.org/10.1007/s10555-016-9608-2

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