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Anthracycline induced inconsistent left ventricular segmental systolic function variation in patients with lymphoma detected by three-dimensional speckle tracking imaging

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Abstract

Chemotherapy contained anthracycline inevitably cause declines of cardiac function. This study evaluated the deterioration of left ventricular segmental systolic function in patients with lymphoma received anthracycline chemotherapy detected by echocardiographic three dimensional speckle tracking imaging (3D-STI). Sixty patients with newly diagnosed diffuse large B-cell lymphoma who received R-CHOP chemotherapy were enrolled. Three dimensional left ventricular global longitudinal strain (3D-GLS), three dimensional left ventricular global circumferential strain (3D-GCS) and three dimensional left ventricular longitudinal strain of different left ventricular segments (3D-LS) were measured by 3D-STI at baseline, after the completion of two cycles and four cycles of the regimen respectively. Compared with baseline, 3D-GLS reduced significantly after four cycles of anthracycline therapy (P < 0.001), while 3D-GCS showed no significant variation during the whole procedure (all P > 0.05). For individual segment, LS of apical anterior and septal walls decreased significantly after two cycles of chemotherapy (all P < 0.05). After four cycles of treatment, 3D-LS of the mid-ventricular level (all P < 0.05), apical level (all P < 0.05) and apex (P < 0.05) worsened. Serum hs-cTnT levels increased after anthracycline exposure (P < 0.05) and Serum hs-cTnT levels were correlated with 3D-GLS at the end of four cycles (r = 0.12, P = 0.03). Mean values of involved segmental 3D-LS of two and four cycles were both correlated with serum hs-cTnT levels at the end of both two and four cycles (r = 0.368, P = 0.041; r = 0.79, p < 0.001). 3D-STI evaluation of the LV provides an understanding of the segmental impairment of LV wall and the possible process of LV impairment in lymphoma patients after anthracycline chemotherapy.

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References

  1. National Comprehensive Cancer Network (2015) Clinical practice guidelines in oncology. Breast Cancer, Version1. IOP Publishing PhysicsWeb. https://www.nccn.org/professionals/physician_3D-GLS/f_guidelines.asp,2015

  2. National Comprehensive Cancer Network (2015) Clinical practice guidelines in oncology. Gastric Cancer, Version1. IOP Publishing PhysicsWeb https://www.nccn.org/professionals/physician_3D-GLS/f_guidelines.asp,2015

  3. National Comprehensive Cancer Network (2015) Clinical practice guidelines in oncology. Hodgkin’s lymphoma, Version1. IOP Publishing PhysicsWeb https://www.nccn.org/professionals/physician_3D-GLS/f_guidelines.asp,2015

  4. Van der pal HJ, Van dalen EC, Van delden E et al (2012) High risk of symptomatic cardiac events in childhood cancer survivors. J Clin Oncol 30:1429–1437

    Article  PubMed  Google Scholar 

  5. Okuma H, Noto N, Tanikawa S, Kanezawa K, Hirai M, Shimozawa K, Yagasaki H, Shichino H, Takahashi S (2017) Impact of persistent left ventricular regional wall motion abnormalities in childhood cancer survivors after anthracycline therapy: assessment of global left ventricular myocardial performance by 3D speckle-tracking echocardiography. J Cardiol 70:396–401

    Article  PubMed  Google Scholar 

  6. Çetin S, Babaoğlu K, Başar EZ, Deveci M, Çorapçıoğlu F (2018) Subclinical anthracycline-induced cardiotoxicity in long-term follow-up of asymptomatic childhood cancer survivors: assessment by speckle tracking echocardiography. Echocardiography 35:234–240

    Article  PubMed  Google Scholar 

  7. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, Picard MH, Roman MJ, Seward J, Shanewise JS, Solomon SD, Spencer KT, Sutton MS, Stewart WJ (2005) Recommendations for chamber quantification: a report from the american society of echocardiography’s guidelines and standards committee and the chamber quantification writing group, developed in conjunction with the european association of echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr 18:1440–1463

    Article  PubMed  Google Scholar 

  8. Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, Pennell DJ, Rumberger JA, Ryan T, Verani MS (2002) Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Int J Cardiovasc Imaging 18:539–542

    PubMed  Google Scholar 

  9. Cardinale D, Colombo A, Bacchiani G, Tedeschi I, Meroni CA, Veglia F, Civelli M, Lamantia G, Colombo N, Curigliano G, Fiorentini C, Cipolla CM (2015) Early detection of anthracycline cardiotoxicity and improvement with heart failure therapy. Circulation 131:1981–1988

    Article  CAS  PubMed  Google Scholar 

  10. Zamorano JL, Lancellotti P, Rodriguez Muñoz D, Aboyans V, Asteggiano R, Galderisi M, Habib G, Lenihan DJ, Lip G, Lyon AR, Lopez Fernandez T, Mohty D, Piepoli MF, Tamargo J, Torbicki A, Suter TM (2016) 2016 ESC position paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC committee for practice guidelines: the task force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC). Eur Heart J 37:2768–2801

    Article  Google Scholar 

  11. Cardinale D, Colombo A, Lamantia G, Colombo N, Civelli M, De Giacomi G, Rubino M, Veglia F, Fiorentini C, Cipolla CM (2010) Anthracycline-induced cardiomyopathy: clinical relevance and response to pharmacologic therapy. J Am Coll Cardiol 55:213–220

    Article  CAS  PubMed  Google Scholar 

  12. Cardinale D, Colombo A, Torrisi R, Sandri MT, Civelli M, Salvatici M, Lamantia G, Colombo N, Cortinovis S, Dessanai MA, Nolè F, Veglia F, Cipolla CM (2010) Trastuzumab-induced cardiotoxicity: clinical and prognostic implications of troponin I evaluation. J Clin Oncol 28:3910–3916

    Article  CAS  PubMed  Google Scholar 

  13. Ewer MS, Ali MK, Mackay B, Wallace S, Valdivieso M, Legha SS, Benjamin RS, Haynie TP (1984) A comparison of cardiac biopsy grades and ejection fraction estimations in patients receiving adriamycin. J Clin Oncol 2:112–117

    Article  CAS  PubMed  Google Scholar 

  14. Lang RM, Badano LP, Tsang W, Adams DH, Agricola E, Buck T, Faletra FF, Franke A, Hung J, de Isla LP, Kamp O, Kasprzak JD, Lancellotti P, Marwick TH, McCulloch ML, Monaghan MJ, Nihoyannopoulos P, Pandian NG, Pellikka PA, Pepi M, Roberson DA, Shernan SK, Shirali GS, Sugeng L, Ten Cate FJ, Vannan MA, Zamorano JL, Zoghbi WA (2012) EAE/ASE recommendations for image acquisition and display using three-dimensional echocardiography. J Am Soc Echocardiogr 25:3–46

    Article  PubMed  Google Scholar 

  15. Cameli M, Mondillo S, Galderisi M, Mandoli GE, Ballo P, Nistri S, Capo V, D’Ascenzi F, D’Andrea A, Esposito R, Gallina S, Montisci R, Novo G, Rossi A, Mele D, Agricola E (2017) Speckle tracking echocardiography: a practical guide. G Ital Cardiol (Rome) 18:253–269

    Google Scholar 

  16. Thavendiranathan P, Poulin F, Lim KD, Plana JC, Woo A, Marwick TH (2014) Use of myocardial strain imaging by echocardiography for the early detection of cardiotoxicity in patients during and after cancer chemotherapy: a systematic review. J Am Coll Cardiol 63:2751–2768

    Article  Google Scholar 

  17. Santoro C, Arpino G, Esposito R, Lembo M, Paciolla I, Cardalesi C, de Simone G, Trimarco B, De Placido S, Galderisi M (2017) 2D and 3D strain for detection of subclinical anthracycline cardiotoxicity in breast cancer patients: a balance with feasibility. Eur Heart J Cardiovasc Imaging 18:930–936

    Article  PubMed  Google Scholar 

  18. Toro-Salazar OH, Ferranti J, Lorenzoni R, Walling S, Mazur W, Raman SV, Davey BT, Gillan E, O’Loughlin M, Klas B, Hor KN (2016) Feasibility of echocardiographic techniques to detect subclinical cancer therapeutics-related cardiac dysfunction among high-dose patients when compared with cardiac magnetic resonance imaging. J Am Soc Echocardiogr 29:119–131

    Article  PubMed  Google Scholar 

  19. Curigliano G, Cardinale D, Suter T, Plataniotis G, de Azambuja E, Sandri MT, Criscitiello C, Goldhirsch A, Cipolla C, Roila F (2012) Cardiovascular toxicity induced by chemotherapy, targeted agents and radiotherapy: ESMO clinical practice guidelines. Ann Oncol 23(Suppl 7):i155–i166

    Article  Google Scholar 

  20. Song FY, Shi J, Guo Y, Zhang CJ, Xu YC, Zhang QL, Shu XH, Cheng LL (2017) Assessment of biventricular systolic strain derived from the two-dimensional and three-dimensional speckle tracking echocardiography in lymphoma patients after anthracycline therapy. Int J Cardiovasc Imaging 33:857–868

    Article  PubMed  Google Scholar 

  21. Mariotto AB, Yabroff KR, Shao Y, Feuer EJ, Brown ML (2011) Projections of the cost of cancer care in the United States: 2010–2020. J Natl Cancer Inst 103:117–128

    Article  PubMed  PubMed Central  Google Scholar 

  22. Van Nimwegen FA, Schaapveld M, Janus CP, Krol AD, Petersen EJ, Raemaekers JM, Kok WE, Aleman BM, van Leeuwen FE (2015) Cardiovascular disease after Hodgkin lymphoma treatment: 40-year disease risk. JAMA Intern Med 175:1007–1017

    Article  PubMed  Google Scholar 

  23. Cuomo JR, Javaheri SP, Sharma GK, Kapoor D, Berman AE, Weintraub NL (2018) How to prevent and manage radiation-induced coronary artery disease. Heart 104:1647–1653

    Article  Google Scholar 

  24. Kapusta L, Groot-Loonen J, Thijssen JM, DeGraaf R, Daniëls O (2003) Regional cardiac wall motion abnormalities during and shortly after anthracyclines therapy. Med Pediatr Oncol 41:426–435

    Article  PubMed  Google Scholar 

  25. Zhang LR, Xu DS, Liu XC (2011) Coronary artery lumen diameter and bifurcation angle derived from CT coronary angiographic image in healthy people. Zhonghua xin xue guan bing za zhi 39(12): 1117–1123

    PubMed  Google Scholar 

  26. Medrano-Gracia P, Ormiston J, Webster M, Beier S, Young A, Ellis C, Wang C, Smedby Ö, Cowan B (2016) A computational atlas of normal coronary artery anatomy. EuroIntervention 12(7): 845–854

    Article  PubMed  Google Scholar 

  27. Cecchi E, Giglioli C, Valente S, Lazzeri C, Gensini GF, Abbate R, Mannini L (2011) Role of hemodynamic shear stress in cardiovascular disease. Atherosclerosis 214:249–256

    Article  CAS  Google Scholar 

  28. Salvucci FP, Perazzo CA, Gurfinkel E, Armentano RL, Barra JG (2010) A patient-specific method for the evaluation of wall shear stress in human coronary arteries. Conf Proc IEEE Eng Med Biol Soc 2010:3788–3791

    CAS  PubMed  Google Scholar 

  29. Pinto SI, Campos JB (2016) Numerical study of wall shear stress-based descriptors in the human left coronary artery. Comput Methods Biomech Biomed Eng 19:1443–1455

    Article  CAS  Google Scholar 

  30. Siasos G, Sara JD, Zaromytidou M, Park KH, Coskun AU, Lerman LO, Oikonomou E, Maynard CC, Fotiadis D, Stefanou K, Papafaklis M, Michalis L, Feldman C, Lerman A, Stone PH (2018) Local low shear stress and endothelial dysfunction in patients with nonobstructive coronary atherosclerosis. J Am Coll Cardiol 71:2092–2102

    Article  PubMed  Google Scholar 

  31. Sengupta PP, Tajik AJ, Chandrasekaran K, Khandheria BK (2008) Twist mechanics of the left ventricle: principles and application. JACC Cardiovasc Imaging 1:366–376

    Article  PubMed  Google Scholar 

  32. Sengupta PP, Khandheria BK, Korinek J, Wang J, Jahangir A, Seward JB, Belohlavek M (2006) Apex-to-base dispersion in regional timing of left ventricular shortening and lengthening. J Am Coll Cardiol 47:163–172

    Article  PubMed  Google Scholar 

  33. Rubini Gimenez M, Badertscher P, Twerenbold R, Boeddinghaus J, Nestelberger T, Wussler D, Miró Ò, Martín-Sánchez FJ, Reichlin T, Mueller C (2018) Impact of the US food and drug administration-approved sex-specific cutoff values for high-sensitivity cardiac troponin t to diagnose myocardial infarction. Circulation 137:1867–1869

    Article  PubMed  Google Scholar 

Download references

Funding

This study was supported by grant 2017BR027 from Municipal Human Resources Development Program for Outstanding Leaders in Medical Disciplines in Shanghai, grant 20164Y0076 from Shanghai Health and Family Planning Commission, 81771840 from National Natural Science Foundation of China.

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Author notes

  1. Yuchen Xu and Jing Shi have contributed equally to this work.

Authors and Affiliations

  1. Department of Echocardiography, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China

    Yuchen Xu, Jing Shi, Rui Zhao, Chujie Zhang, Yiyao He, Xianhong Shu & Leilei Cheng

  2. Shanghai Institute of Cardiovascular Diseases, Shanghai Institute of Medical Imaging, Fudan University, 180 Fenglin Road, Shanghai, 200032, China

    Yuchen Xu, Jing Shi, Rui Zhao, Chujie Zhang, Yiyao He, Xianhong Shu & Leilei Cheng

  3. Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Fudan University, 180 Fenglin Road, Shanghai, China

    Jinyi Lin

  4. Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China

    Qunling Zhang

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  1. Yuchen Xu
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Correspondence to Leilei Cheng.

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All authors declare no conflicts of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Xu, Y., Shi, J., Zhao, R. et al. Anthracycline induced inconsistent left ventricular segmental systolic function variation in patients with lymphoma detected by three-dimensional speckle tracking imaging. Int J Cardiovasc Imaging 35, 771–779 (2019). https://doi.org/10.1007/s10554-018-1510-2

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  • DOI: https://doi.org/10.1007/s10554-018-1510-2

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