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A systematic review of imaging anatomy in predicting functional significance of coronary stenoses determined by fractional flow reserve

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Abstract

Fractional flow reserve (FFR) is the current gold standard to assess the physiological significance of coronary stenoses. With the development of coronary imaging techniques, several anatomic parameters have been investigated in vivo and their associations with FFR have been studied. The aim of this review is to summarize the accuracy of anatomic parameters derived by the present coronary imaging techniques including invasive coronary angiography, coronary computed tomography angiography, intravascular ultrasound and optical coherence tomography, in predicting a significant FFR. The impact of patient characteristics, lesion locations, variability of FFR and imaging resolution on the predictive ability are discussed.

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Acknowledgements

Dr. Tu acknowledges the support by The Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning, The Shanghai Pujiang Program (No. 15PJ1404200), the National Natural Science Foundation of China (Grants 31500797 and 81570456) and the National Key Research and Development Program of China (Grant 2016YFC0100500). Dr. Dai acknowledges the support by National Natural Science Foundation of China (Grant 81600279).

Disclosures

ST and JW received research Grant from Medis medical imaging systems bv.

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    Authors and Affiliations

    1. Biomedical Instrument Institute, School of Biomedical Engineering, Med-X Research Institute, Shanghai Jiao Tong University, No. 1954, Hua Shan Road, Shanghai, 200030, China

      Miao Chu & Shengxian Tu

    2. Cardiovascular Department, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China

      Neng Dai

    3. The 3rd Division of Cardiology, Department of Cardiology, Guangdong General Hospital, Guangdong Provincial Cardiovascular Institute, Guangdong Academy of Medical Sciences, No.106, 2nd Zhongshan Road, Yuexiu district, Guangzhou, Guangdong, 510080, China

      Junqing Yang

    4. Department of Cardiology, Aarhus University Hospital, Skejby, Denmark

      Jelmer Westra

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    Correspondence to Junqing Yang or Shengxian Tu.

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    S. Tu has received a research grant from Medis medical imaging systems bv. All other authors declare that they have no conflict of interest.

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    Miao Chu and Neng Dai have contributed equally to this work.

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    Chu, M., Dai, N., Yang, J. et al. A systematic review of imaging anatomy in predicting functional significance of coronary stenoses determined by fractional flow reserve. Int J Cardiovasc Imaging 33, 975–990 (2017). https://doi.org/10.1007/s10554-017-1085-3

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    • DOI: https://doi.org/10.1007/s10554-017-1085-3

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