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Early vascular healing after titanium–nitride–oxide-coated stent versus platinum–chromium everolimus-eluting stent implantation in patients with acute coronary syndrome

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Abstract

Data on early vascular healing response of novel stent designs are scarce. In this randomized prospective trial, we sought to compare early neointimal coverage of cobalt–chromium-based titanium–nitride–oxide-coated bioactive stents (CoCr-BAS) versus platinum–chromium everolimus-eluting stents (PtCr-EES) at 2-month follow-up in patients with acute coronary syndrome (ACS). Forty patients with ACS were randomized to receive either CoCr-BAS (n = 19) or PtCr-EES (n = 21). Neointimal strut coverage and strut apposition were examined by optical coherence tomography; and coronary flow reserve (CFR), fractional flow reserve (FFR) and index of microcirculatory resistance (IMR) were assessed using a coronary pressure wire at 2 months. Two patients in the PtCr-EES underwent OCT out of the time frame of the study, and were excluded from analysis. At 63 ± 8 days, 302 cross-sections (3412 struts) were analysed in the CoCr-BAS group, and 324 cross-sections (3460 struts) in the PtCr-EES group. Median [IQR] neointimal thickness was 203 [108] µm and 42.2 [41] µm for CoCr-BAS and PtCr-EES, respectively (p < 0.001). Median [IQR] percentage of uncovered struts was 1.2 [2.8] % versus 11.3 [17.7] %, respectively (p < 0.001). Flow measurements were comparable between the two groups (p > 0.05 for all). CoCr-BAS showed earlier and more adequate neointimal coverage of struts at 2 months, compared with PtCr-EES, but with more neointimal hyperplasia. Functional healing as assessed by CFR, FFR, and IMR was similar between the two stent arms.

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Acknowledgments

Authors deeply thank RN Minna Ampio, RN Kristiina Lahtonen and RN Tuija Vasankari for their excellent technical assistance. This study was supported by Scholarship for research within the area of Acute Coronary Syndrome from the Finnish Cardiac Society (T.K.); by grants from the Finnish Foundation for Cardiovascular Research, Helsinki, Finland (T.K. and J.A.); and by Turku University Hospital Research Foundation.

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Authors and Affiliations

  1. Heart Centre, Turku University Hospital, University of Turku, Hämeentie 9, 20520, Turku, Finland

    Ville Varho, Tuomas O. Kiviniemi, Wail Nammas, Mikko Pietilä & Juhani K. Airaksinen

  2. Department of Cardiology, Central Ostrobothnia Central Hospital, Kokkola, Finland

    Jussi Sia

  3. Cardiology Unit, Kuopio University Hospital, Kuopio, Finland

    Hannu Romppanen & Anssi Perälä

  4. Heart Centre, Satakunta Central Hospital, Pori, Finland

    Jussi Mikkelsson, Petri Tuomainen & Pasi P. Karjalainen

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  1. Ville Varho
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Correspondence to Ville Varho.

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Varho, V., Kiviniemi, T.O., Nammas, W. et al. Early vascular healing after titanium–nitride–oxide-coated stent versus platinum–chromium everolimus-eluting stent implantation in patients with acute coronary syndrome. Int J Cardiovasc Imaging 32, 1031–1039 (2016). https://doi.org/10.1007/s10554-016-0871-7

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