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Diagnostic accuracy of late iodine enhancement on cardiac computed tomography with a denoise filter for the evaluation of myocardial infarction

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Abstract

We evaluated the image quality and diagnostic performance of late iodine enhancement (LIE) in dual-source computed tomography (DSCT) with low kilo-voltage peak (kVp) images and a denoise filter for the detection of acute myocardial infarction (AMI) in comparison with late gadolinium enhancement (LGE) magnetic resonance imaging (MRI). The Hospital Ethics Committee approved the study protocol. Before discharge, 19 patients who received percutaneous coronary intervention after AMI underwent DSCT and 1.5 T MRI. Immediately after coronary computed tomography (CT) angiography, contrast medium was administered at a slow injection rate. LIE-CT scans were acquired via dual-energy CT and reconstructed as 100-, 140-kVp, and mixed images. An iterative three-dimensional edge-preserved smoothing filter was applied to the 100-kVp images to obtain denoised 100-kVp images. The mixed, 140-kVp, 100-kVp, and denoised 100-kVp images were assessed using contrast-to-noise ratio (CNR), and their diagnostic performance in comparison with MRI and infarcted volumes were evaluated. Three hundred four segments of 19 patients were evaluated. Fifty-three segments showed LGE in MRI. The median CNR of the mixed, 140-, 100-kVp and denoised 100-kVp images was 3.49, 1.21, 3.57, and 6.08, respectively. The median CNR was significantly higher in the denoised 100-kVp images than in the other three images (P < 0.05). The denoised 100-kVp images showed the highest diagnostic accuracy and sensitivity. The percentage of myocardium in the four CT image types was significantly correlated with the respective MRI findings. The use of a denoise filter with a low-kVp image can improve CNR, sensitivity, and accuracy in LIE-CT.

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Authors and Affiliations

  1. Department of Radiology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan

    Takuya Matsuda, Teruhito Kido & Teruhito Mochizuki

  2. Research and Collaboration, Siemens Japan, Shinagawa, Tokyo, Japan

    Toshihide Itoh

  3. Department of Cardiology, Saiseikai Matsuyama Hospital, Matsuyama, Ehime, Japan

    Hideyuki Saeki, Susumu Shigemi & Kouki Watanabe

  4. Department of Radiology, Saiseikai Matsuyama Hospital, Matsuyama, Ehime, Japan

    Tomoyuki Kido, Shoji Aono & Masaya Yamamoto

  5. Department of Radiology, Matsuyama Red Cross Hospital, Matsuyama, Ehime, Japan

    Takeshi Matsuda

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  1. Takuya Matsuda
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  2. Teruhito Kido
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  4. Hideyuki Saeki
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  9. Masaya Yamamoto
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  10. Takeshi Matsuda
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Correspondence to Takuya Matsuda.

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Conflict of interest

Takuya Matsuda declares that he has no conflict of interest. Teruhito Kido declares that he has no conflict of interest. Toshihide Itoh is an employee of Siemens Japan. Hideyuki Saeki declares that he has no conflict of interest. Susumu Shigemi declares that he has no conflict of interest. Kouki Watanabe declares that he has no conflict of interest. Tomoyuki Kido declares that he has no conflict of interest. Shoji Aono declares that he has no conflict of interest. Masaya Yamamoto declares that he has no conflict of interest. Takeshi Matsuda declares that he has no conflict of interest. Teruhito Mochizuki declares that he has no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Matsuda, T., Kido, T., Itoh, T. et al. Diagnostic accuracy of late iodine enhancement on cardiac computed tomography with a denoise filter for the evaluation of myocardial infarction. Int J Cardiovasc Imaging 31 (Suppl 2), 177–185 (2015). https://doi.org/10.1007/s10554-015-0716-9

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  • DOI: https://doi.org/10.1007/s10554-015-0716-9

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