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Alcohol intake and the risk of epithelial ovarian cancer

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Abstract

Purpose

To investigate the association between alcohol intake over the lifetime and the risk of overall, borderline, and invasive ovarian cancer.

Methods

In a population-based case–control study of 495 cases and 902 controls, conducted in Montreal, Canada, average alcohol intake over the lifetime and during specific age periods were computed from a detailed assessment of the intake of beer, red wine, white wine and spirits. Multivariable logistic regression was used to estimate odds ratios (ORs) with 95% confidence intervals (CIs) for the association between alcohol intake and ovarian cancer risk.

Results

For each one drink/week increment in average alcohol intake over the lifetime, the adjusted OR (95% CI) was 1.06 (1.01–1.10) for ovarian cancer overall, 1.13 (1.06–1.20) for borderline ovarian cancers and 1.02 (0.97–1.08) for invasive ovarian cancers. This pattern of association was similarly observed for alcohol intake in early (15– < 25 years), mid (25– < 40 years) and late adulthood (≥ 40 years), as well as for the intake of specific alcohol beverages over the lifetime.

Conclusions

Our results support the hypothesis that a higher alcohol intake modestly increases the risk of overall ovarian cancer, and more specifically, borderline tumours.

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Data availability

Data are available upon request.

Abbreviations

CI:

Confidence interval

DAG:

Directed acyclic graph

OR:

Odds ratio

PROVAQ:

Prevention of ovarian cancer in Quebec

References

  1. Reade CJ, Riva JJ, Busse JW, Goldsmith CH, Elit L (2013) Risks and benefits of screening asymptomatic women for ovarian cancer: a systematic review and meta-analysis. Gynecol Oncol 130:674–681. https://doi.org/10.1016/j.ygyno.2013.06.029

    Article  PubMed  Google Scholar 

  2. Reid BM, Permuth JB, Sellers TA (2017) Epidemiology of ovarian cancer: a review. Cancer Biol Med 14:9–32. https://doi.org/10.20892/j.issn.2095-3941.2016.0084

  3. Henderson JT, Webber EM, Sawaya GF (2018) Screening for ovarian cancer: updated evidence report and systematic review for the US preventive services task force. JAMA 319:595–606. https://doi.org/10.1001/jama.2017.21421

    Article  PubMed  Google Scholar 

  4. Menon U, Gentry-Maharaj A, Burnell M et al (2021) Ovarian cancer population screening and mortality after long-term follow-up in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial. Lancet. https://doi.org/10.1016/S0140-6736(21)00731-5

    Article  PubMed  PubMed Central  Google Scholar 

  5. IARC (2010) Alcohol consumption and ethyl carbamate. IARC Monogr Eval Carcinog Risks Hum 96:1–1428

    Google Scholar 

  6. World Cancer Research Fund (2018) Alcoholic drinks and the risk of Cancer

  7. Seitz HK, Stickel F (2007) Molecular mechanisms of alcohol-mediated carcinogenesis. Nat Rev Cancer 7:599–612. https://doi.org/10.1038/nrc2191

    Article  CAS  PubMed  Google Scholar 

  8. Snopek L, Mlcek J, Sochorova L et al (2018) Contribution of red wine consumption to human health protection. Molecules. https://doi.org/10.3390/molecules23071684

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Chang ET, Canchola AJ, Lee VS et al (2007) Wine and other alcohol consumption and risk of ovarian cancer in the California Teachers Study cohort. Cancer Causes Control 18:91–103

    Article  PubMed  PubMed Central  Google Scholar 

  10. Peterson NB, Trentham-Dietz A, Newcomb PA et al (2006) Alcohol consumption and ovarian cancer risk in a population-based case-control study. Int J Cancer 119:2423–2427

    Article  CAS  PubMed  Google Scholar 

  11. Goodman MT, Tung KH (2003) Alcohol consumption and the risk of borderline and invasive ovarian cancer. Obstet Gynecol 101:1221–1228

    CAS  PubMed  Google Scholar 

  12. La Vecchia C, Negri E, Franceschi S, Parazzini F, Gentile A, Fasoli M (1992) Alcohol and epithelial ovarian cancer. J Clin Epidemiol 45:1025–1030

    Article  PubMed  Google Scholar 

  13. Tavani A, Gallus S, Dal Maso L et al (2001) Coffee and alcohol intake and risk of ovarian cancer: an Italian case–control study. Nutr Cancer 39:29–34. https://doi.org/10.1207/S15327914nc391_4

    Article  CAS  PubMed  Google Scholar 

  14. Modugno F, Ness RB, Allen GO (2003) Alcohol consumption and the risk of mucinous and nonmucinous epithelial ovarian cancer. Obstet Gynecol 102:1336–1343

    CAS  PubMed  Google Scholar 

  15. Allen NE, Beral V, Casabonne D et al (2009) Moderate alcohol intake and cancer incidence in women. J Natl Cancer Inst 101:296–305. https://doi.org/10.1093/jnci/djn514

    Article  PubMed  Google Scholar 

  16. Gwinn ML, Webster LA, Lee NC, Layde PM, Rubin GL (1986) Alcohol consumption and ovarian cancer risk. Am J Epidemiol 123:759–766

    Article  CAS  PubMed  Google Scholar 

  17. Hartge P, Schiffman MH, Hoover R, McGowan L, Lesher L, Norris HJ (1989) A case–control study of epithelial ovarian cancer. Am J Obstet Gynecol 161:10–16. https://doi.org/10.1016/0002-9378(89)90221-4

    Article  CAS  PubMed  Google Scholar 

  18. Kelemen LE, Sellers TA, Vierkant RA, Harnack L, Cerhan JR (2004) Association of folate and alcohol with risk of ovarian cancer in a prospective study of postmenopausal women. Cancer Causes Control 15:1085–1093. https://doi.org/10.1007/s10552-004-1546-6

    Article  PubMed  Google Scholar 

  19. Kuper H, Titus-Ernstoff L, Harlow BL, Cramer DW (2000) Population based study of coffee, alcohol and tobacco use and risk of ovarian cancer. Int J Cancer 88:313–318. https://doi.org/10.1002/1097-0215(20001015)88:2

    Article  CAS  PubMed  Google Scholar 

  20. McCann SE, Freudenheim JL, Marshall JR, Graham S (2003) Risk of human ovarian cancer is related to dietary intake of selected nutrients, phytochemicals and food groups. J Nutr 133:1937–1942. https://doi.org/10.1093/jn/133.6.1937

    Article  CAS  PubMed  Google Scholar 

  21. Mori M, Harabuchi I, Miyake H, Casagrande JT, Henderson BE, Ross RK (1988) Reproductive, genetic, and dietary risk factors for ovarian cancer. Am J Epidemiol 128:771–777. https://doi.org/10.1093/oxfordjournals.aje.a115030

    Article  CAS  PubMed  Google Scholar 

  22. Polychronopoulou A, Tzonou A, Hsieh CC et al (1993) Reproductive variables, tobacco, ethanol, coffee and somatometry as risk factors for ovarian cancer. Int J Cancer 55:402–407. https://doi.org/10.1002/ijc.2910550312

    Article  CAS  PubMed  Google Scholar 

  23. Schouten LJ, Zeegers MP, Goldbohm RA, van den Brandt PA (2004) Alcohol and ovarian cancer risk: results from the Netherlands Cohort Study. Cancer Causes Control 15:201–209

    Article  PubMed  Google Scholar 

  24. Tworoger SS, Gertig DM, Gates MA, Hecht JL, Hankinson SE (2008) Caffeine, alcohol, smoking, and the risk of incident epithelial ovarian cancer. Cancer 112:1169–1177. https://doi.org/10.1002/cncr.23275

    Article  PubMed  Google Scholar 

  25. Weiderpass E, Sandin S, Inoue M et al (2012) Risk factors for epithelial ovarian cancer in Japan—results from the Japan Public Health Center-based Prospective Study cohort. Int J Oncol 40:21–30. https://doi.org/10.3892/ijo.2011.1194

    Article  PubMed  Google Scholar 

  26. Whittemore AS, Wu ML, Paffenbarger RS Jr et al (1988) Personal and environmental characteristics related to epithelial ovarian cancer. II. Exposures to talcum powder, tobacco, alcohol, and coffee. Am J Epidemiol 128:1228–1240. https://doi.org/10.1093/oxfordjournals.aje.a115077

    Article  CAS  PubMed  Google Scholar 

  27. Yen ML, Yen BL, Bai CH, Lin RS (2003) Risk factors for ovarian cancer in Taiwan: a case–control study in a low-incidence population. Gynecol Oncol 89:318–324

    Article  PubMed  Google Scholar 

  28. Nandakumar A, Anantha N, Dhar M et al (1995) A case–control investigation on cancer of the ovary in Bangalore, India. Int J Cancer 63:361–365. https://doi.org/10.1002/ijc.2910630310

    Article  CAS  PubMed  Google Scholar 

  29. Riman T, Dickman PW, Nilsson S et al (2001) Risk factors for epithelial borderline ovarian tumors: results of a Swedish case–control study. Gynecol Oncol 83:575–585. https://doi.org/10.1006/gyno.2001.6451

    Article  CAS  PubMed  Google Scholar 

  30. Riman T, Dickman PW, Nilsson S, Nordlinder H, Magnusson CM, Persson IR (2004) Some life-style factors and the risk of invasive epithelial ovarian cancer in Swedish women. Eur J Epidemiol 19:1011–1019. https://doi.org/10.1007/s10654-004-1633-8

    Article  PubMed  Google Scholar 

  31. Navarro Silvera SA, Jain M, Howe GR, Miller AB, Rohan TE (2006) Dietary folate consumption and risk of ovarian cancer: a prospective cohort study. Eur J Cancer Prev 15:511–515. https://doi.org/10.1097/01.cej.0000220627.54986.bf

    Article  PubMed  Google Scholar 

  32. Kelemen LE, Bandera EV, Terry KL et al (2013) Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium. BMC Cancer 13:28. https://doi.org/10.1186/1471-2407-13-28

    Article  PubMed  PubMed Central  Google Scholar 

  33. Larsson SC, Giovannucci E, Wolk A (2004) Dietary folate intake and incidence of ovarian cancer: the Swedish Mammography Cohort. J Natl Cancer Inst 96:396–402. https://doi.org/10.1093/jnci/djh061

    Article  CAS  PubMed  Google Scholar 

  34. Genkinger JM, Hunter DJ, Spiegelman D et al (2006) Alcohol intake and ovarian cancer risk: a pooled analysis of 10 cohort studies. Br J Cancer 94:757–762. https://doi.org/10.1038/sj.bjc.6603020

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Byers T, Marshall J, Graham S, Mettlin C, Swanson M (1983) A case-control study of dietary and nondietary factors in ovarian cancer. J Natl Cancer Inst 71:681–686

    CAS  PubMed  Google Scholar 

  36. Godard B, Foulkes WD, Provencher D et al (1998) Risk factors for familial and sporadic ovarian cancer among French Canadians: a case–control study. Am J Obstet Gynecol 179:403–410. https://doi.org/10.1016/s0002-9378(98)70372-2

    Article  CAS  PubMed  Google Scholar 

  37. Tzonou A, Day NE, Trichopoulos D et al (1984) The epidemiology of ovarian cancer in Greece: a case–control study. Eur J Cancer Clin Oncol 20:1045–1052. https://doi.org/10.1016/0277-5379(84)90107-x

    Article  CAS  PubMed  Google Scholar 

  38. Harris HR, Cramer DW, Vitonis AF, DePari M, Terry KL (2012) Folate, vitamin B(6), vitamin B(12), methionine and alcohol intake in relation to ovarian cancer risk. Int J Cancer 131:E518–E529. https://doi.org/10.1002/ijc.26455

    Article  CAS  PubMed  Google Scholar 

  39. Kato I, Tominaga S, Terao C (1989) Alcohol consumption and cancers of hormone-related organs in females. Jpn J Clin Oncol 19:202–207

    CAS  PubMed  Google Scholar 

  40. Kushi LH, Mink PJ, Folsom AR et al (1999) Prospective study of diet and ovarian cancer. Am J Epidemiol 149:21–31

    Article  CAS  PubMed  Google Scholar 

  41. Webb PM, Purdie DM, Bain CJ, Green AC (2004) Alcohol, wine, and risk of epithelial ovarian cancer. Cancer Epidemiol Biomarkers Prev 13:592–599

    Article  CAS  PubMed  Google Scholar 

  42. Cook LS, Leung AC, Swenerton K et al (2016) Adult lifetime alcohol consumption and invasive epithelial ovarian cancer risk in a population-based case–control study. Gynecol Oncol 140:277–284. https://doi.org/10.1016/j.ygyno.2015.12.005

    Article  CAS  PubMed  Google Scholar 

  43. Hunn J, Rodriguez GC (2012) Ovarian cancer: etiology, risk factors, and epidemiology. Clin Obstet Gynecol 55:3–23. https://doi.org/10.1097/GRF.0b013e31824b4611

    Article  PubMed  Google Scholar 

  44. Holligan SD, Battista K, de Groh M, Jiang Y, Leatherdale ST (2019) Age at first alcohol use predicts current alcohol use, binge drinking and mixing of alcohol with energy drinks among Ontario Grade 12 students in the COMPASS study. Health Promot Chronic Dis Prev Can 39:298–305. https://doi.org/10.24095/hpcdp.39.11.02

  45. Clarke MA, Joshu CE (2017) Early life exposures and adult cancer risk. Epidemiol Rev 39:11–27. https://doi.org/10.1093/epirev/mxx004

    Article  PubMed  PubMed Central  Google Scholar 

  46. Prat J (2017) Pathology of borderline and invasive cancers. Best Pract Res Clin Obstet Gynaecol 41:15–30. https://doi.org/10.1016/j.bpobgyn.2016.08.007

    Article  PubMed  Google Scholar 

  47. Koushik A, Grundy A, Abrahamowicz M et al (2017) Hormonal and reproductive factors and the risk of ovarian cancer. Cancer Causes Control 28:393–403. https://doi.org/10.1007/s10552-016-0848-9

    Article  PubMed  Google Scholar 

  48. Rotermann M et al. (2012) Oral contraceptive use among women aged 15 to 49: Results from the Canadian Health Measures Survey. https://www150.statcan.gc.ca/n1/pub/82-003-x/2015010/article/14222-eng.htm.

  49. Costanian C, McCague H, Tamim H (2018) Age at natural menopause and its associated factors in Canada: cross-sectional analyses from the Canadian Longitudinal Study on Aging. Menopause 25:265–272. https://doi.org/10.1097/GME.0000000000000990

    Article  PubMed  Google Scholar 

  50. Evans D, Chaix B, Lobbedez T, Verger C, Flahault A (2012) Combining directed acyclic graphs and the change-in-estimate procedure as a novel approach to adjustment-variable selection in epidemiology. BMC Med Res Methodol 12:156. https://doi.org/10.1186/1471-2288-12-156

    Article  PubMed  PubMed Central  Google Scholar 

  51. Leffondre K, Abrahamowicz M, Siemiatycki J, Rachet B (2002) Modeling smoking history: a comparison of different approaches. Am J Epidemiol 156:813–823. https://doi.org/10.1093/aje/kwf122

    Article  PubMed  Google Scholar 

  52. Lorenz E, Jenkner C, Sauerbrei W, Becher H (2017) Modeling variables with a spike at zero: examples and practical recommendations. Am J Epidemiol 185:650–660. https://doi.org/10.1093/aje/kww122

    Article  PubMed  Google Scholar 

  53. Ng Fat L, Cable N, Marmot MG, Shelton N (2014) Persistent long-standing illness and non-drinking over time, implications for the use of lifetime abstainers as a control group. J Epidemiol Community Health 68:71–77. https://doi.org/10.1136/jech-2013-202576

    Article  PubMed  Google Scholar 

  54. Robertson C, Boyle P, Hsieh CC, Macfarlane GJ, Maisonneuve P (1994) Some statistical considerations in the analysis of case-control studies when the exposure variables are continuous measurements. Epidemiology 5:164–170. https://doi.org/10.1097/00001648-199403000-00006

    Article  CAS  PubMed  Google Scholar 

  55. Royston P, Ambler G, Sauerbrei W (1999) The use of fractional polynomials to model continuous risk variables in epidemiology. Int J Epidemiol 28:964–974

    Article  CAS  PubMed  Google Scholar 

  56. Statistics Canada (2019) Canadian Alcohol and Drugs Survey (CADS): 2019 detailed tables

  57. Manthey J, Shield KD, Rylett M, Hasan OSM, Probst C, Rehm J (2019) Global alcohol exposure between 1990 and 2017 and forecasts until 2030: a modelling study. Lancet 393:2493–2502. https://doi.org/10.1016/S0140-6736(18)32744-2

    Article  PubMed  Google Scholar 

  58. Sherk A, Thomas G, Churchill S, Stockwell T (2020) Does drinking within low-risk guidelines prevent harm? Implications for high-income countries using the international model of alcohol harms and policies. J Stud Alcohol Drugs 81:352–361

    Article  PubMed  Google Scholar 

  59. Jayasekara H, MacInnis RJ, Williamson EJ et al (2017) Lifetime alcohol intake is associated with an increased risk of KRAS+ and BRAF−/KRAS− but not BRAF+ colorectal cancer. Int J Cancer 140:1485–1493. https://doi.org/10.1002/ijc.30568

    Article  CAS  PubMed  Google Scholar 

  60. Mayr D, Hirschmann A, Lohrs U, Diebold J (2006) KRAS and BRAF mutations in ovarian tumors: a comprehensive study of invasive carcinomas, borderline tumors and extraovarian implants. Gynecol Oncol 103:883–887. https://doi.org/10.1016/j.ygyno.2006.05.029

    Article  CAS  PubMed  Google Scholar 

  61. Sun Y, Xu J, Jia X (2020) The diagnosis, treatment, prognosis and molecular pathology of borderline ovarian tumors: current status and perspectives. Cancer Manag Res 12:3651–3659. https://doi.org/10.2147/CMAR.S250394

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  62. Kim HS, Kim JW, Shouten LJ et al (2010) Wine drinking and epithelial ovarian cancer risk: a meta-analysis. J Gynecol Oncol 21:112–118. https://doi.org/10.3802/jgo.2010.21.2.112

    Article  PubMed  PubMed Central  Google Scholar 

  63. Schwarz N (1999) Self-reports: how the questions shape the answers. Am Psychol 54:93–105. https://doi.org/10.1037/0003-066X.54.2.93

    Article  Google Scholar 

  64. Glasner T, van der Vaart W (2009) Applications of calendar instruments in social surveys: a review. Qual Quant 43:333–349. https://doi.org/10.1007/s11135-007-9129-8

    Article  PubMed  Google Scholar 

  65. Giovannucci E, Stampfer MJ, Colditz GA et al (1993) Recall and selection bias in reporting past alcohol consumption among breast cancer cases. Cancer Causes Control 4:441–448. https://doi.org/10.1007/BF00050863

    Article  CAS  PubMed  Google Scholar 

  66. Collins SE (2016) Associations between socioeconomic factors and alcohol outcomes. Alcohol Res 38:83–94

    PubMed  PubMed Central  Google Scholar 

  67. Katikireddi SV, Whitley E, Lewsey J, Gray L, Leyland AH (2017) Socioeconomic status as an effect modifier of alcohol consumption and harm: analysis of linked cohort data. Lancet Public Health 2:e267–e276. https://doi.org/10.1016/S2468-2667(17)30078-6

    Article  PubMed  PubMed Central  Google Scholar 

  68. Rosoff DB, Clarke TK, Adams MJ et al (2019) Educational attainment impacts drinking behaviors and risk for alcohol dependence: results from a two-sample Mendelian randomization study with ~780,000 participants. Mol Psychiatry. https://doi.org/10.1038/s41380-019-0535-9

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  69. Hernan MA, Hernandez-Diaz S, Robins JM (2004) A structural approach to selection bias. Epidemiology 15:615–625

    Article  PubMed  Google Scholar 

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Funding

Data collection in the PROVAQ study was supported by the Canadian Cancer Society (Grant #700485); and the Cancer Research Society, the Fonds de recherché du Québec-Santé, and the Ministère de l’Économie de la Science et de l’Innovation du Québec GRePEC program (Grant #16264). The sponsors had no role in the design, data collection, data analysis, interpretation of the results, the preparation of the manuscript, or the decision to submit the manuscript for publication.

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Authors and Affiliations

  1. Université de Montréal Hospital Research Centre (CRCHUM), Tour Saint-Antoine, 850 Rue Saint-Denis, 3e étage, Bureau S03.436, Montreal, QC, H2X 0A9, Canada

    Kevin L’Espérance, Anne Grundy, Diane Provencher & Anita Koushik

  2. Department of Social and Preventive Medicine, Université de Montréal, Montreal, QC, Canada

    Kevin L’Espérance & Anita Koushik

  3. Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada

    Michal Abrahamowicz

  4. Department of Pathology, McGill University Health Centre, Montreal, QC, Canada

    Jocelyne Arseneau

  5. Division of Gynecologic Oncology, McGill University Health Centre, Montreal, QC, Canada

    Jocelyne Arseneau & Lucy Gilbert

  6. Gynecologic Oncology and Colposcopy, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, QC, Canada

    Walter H. Gotlieb

  7. Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Centre Hospitalier de l’Université de Montréal, Montreal, QC, Canada

    Diane Provencher

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  1. Kevin L’Espérance
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  2. Anne Grundy
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  8. Anita Koushik
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Contributions

Conceptualization: KL, MA and AK; methodology: KL, MA, and AK; validation: KL, JA; formal analysis: KL; data curation: KL and AG; writing (original draft): KL and AK; writing (review and editing): KL, MA, AG, JA, LG, WHG and DP; resources: LG, WHG and DP; visualization: KL and AK; supervision, project administration and funding acquisition: AK.

Corresponding author

Correspondence to Anita Koushik.

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The authors declare no competing interests.

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The authors declare no competing interests

Ethics approval

The PROVAQ study was approved by the Research Ethics Committee of the Centre de recherche du CHUM as well as the participating hospitals. This research was conducted in line with the principles of the Declaration of Helsinki and its later amendments or comparable ethical standards.

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Informed consent was obtained for all individual participants included in this study.

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L’Espérance, K., Grundy, A., Abrahamowicz, M. et al. Alcohol intake and the risk of epithelial ovarian cancer. Cancer Causes Control 34, 533–541 (2023). https://doi.org/10.1007/s10552-023-01681-3

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