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Ovarian Cancer in Women of African Ancestry (OCWAA) consortium: a resource of harmonized data from eight epidemiologic studies of African American and white women

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Abstract

Purpose

Although the incidence rate of epithelial ovarian cancer (EOC) is somewhat lower in African American (AA) than white women, survival is worse. The Ovarian Cancer in Women of African Ancestry (OCWAA) consortium will overcome small, study-specific sample sizes to better understand racial differences in EOC risk and outcomes.

Methods

We harmonized risk factors and prognostic characteristics from eight U.S. studies: the North Carolina Ovarian Cancer Study (NCOCS), the Los Angeles County Ovarian Cancer Study (LACOCS), the African American Cancer Epidemiology Study (AACES), the Cook County Case–Control Study (CCCCS), the Black Women’s Health Study (BWHS), the Women’s Health Initiative (WHI), the Multiethnic Cohort Study (MEC), and the Southern Community Cohort Study (SCCS).

Results

Determinants of disparities for risk and survival in 1,146 AA EOC cases and 2,922 AA controls will be compared to 3,368 white EOC cases and 10,270 white controls. Analyses include estimation of population-attributable risk percent (PAR%) by race.

Conclusion

OCWAA is uniquely positioned to study the epidemiology of EOC in AA women compared with white women to address disparities. Studies of EOC have been underpowered to address factors that may explain AA-white differences in the incidence and survival. OCWAA promises to provide novel insight into disparities in ovarian cancer.

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Acknowledgments

The authors thank the WHI investigators and staff for their dedication and the study participants for making the program possible. A full listing of WHI investigators can be found at: http://www.whi.org/researchers/Documents%20%20Write%20a%20Paper/WHI%20Investigator%20Long%20List.pdf. The authors would also like to thank Alpana Kaushiva for harmonizing the data from the Cook County Case–Control Study. Additionally, the authors sincerely thank the state cancer registries that contributed to the OCWAA studies: Arizona, Arkansas, California, Colorado, Connecticut, Delaware, District of Columbia, Florida, Georgia, Hawaii, Illinois, Indiana, Kentucky, Louisiana, Maryland, Massachusetts, Michigan, Mississippi, New Jersey, New York, North Carolina, Oklahoma, Pennsylvania, South Carolina, Tennessee, Texas, Virginia, and West Virginia.

Funding

This project is supported by grant R01-CA207260 (L.A. Rosenberg, J.M. Schildkraut) from the National Cancer Institute (NCI), National Institutes of Health (NIH), U.S. Department of Health and Human Services. In addition, AACES was funded by NCI (R01-CA142081; J.M. Schildkraut); BWHS is funded by NIH (R01-CA058420 and UM1CA164974); CCCCS was funded by NIH/NCI (R01-CA61093; K.A. Rosenblatt); LACOCS was funded by NCI (R01-CA17054 [Pike], R01-CA58598 [Goodman, A. Wu] and Cancer Center Core Grant P30-CA014089 [Henderson, A. Wu]) and the California Cancer Research Program (2II0200 [A. Wu]); and NCOCS was funded by NCI (R01-CA076016; J.M. Schildkraut). SCCS is supported by the NCI (Grants R01-CA092447 and U01-CA202979; W.J. Blot and W. Zheng), and data collection is performed by the Survey and Biospecimen Shared Resource, which is supported by the Vanderbilt-Ingram Cancer Center (P30-CA68485). In addition, support to bring SCCS to OCWAA was provided by a Pilot Award (PI: Beeghly-Fadiel) from the NIH Precision Medicine and Health Disparities Collaborative (NIMHD/NHGRI U54-MD010722). The WHI program is funded by the National Heart, Lung, and Blood Institute, NIH through contracts HHSN268201600018C, HHSN268201600001C, HHSN268201600002C, HHSN268201600003C, and HHSN268201600004C. Additionally, WHI, “The women’s health Initiative Cancer Survivor Cohort,” is funded by NCI (5UM1CA173642-05; G.L. Anderson).

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Authors and Affiliations

  1. Department of Public Health Sciences, University of Virginia, PO Box 800765, Charlottesville, VA, 22903, USA

    Joellen M. Schildkraut, Fabian Camacho, Deanna Chyn & Emily K. Cloyd

  2. Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA

    Lauren C. Peres

  3. Slone Epidemiology Center, Boston University, Boston, MA, USA

    Traci N. Bethea & Lynn Rosenberg

  4. Department of Population Science, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA

    Elisa V. Bandera

  5. Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA

    Alicia Beeghly-Fadiel & Loren Lipworth

  6. Department of Ophthalmology and Visual Sciences, Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago School of Medicine, Chicago, IL, USA

    Charlotte E. Joslin

  7. School of Public Health Sciences, University of Alberta, Edmonton, AB, Canada

    Faith G. Davis

  8. Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA

    Patricia G. Moorman

  9. Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA

    Evan Myers

  10. Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, The State University of New York, Buffalo, NY, USA

    Heather M. Ochs-Balcom

  11. University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA

    Veronica Wendy Setiawan

  12. Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Malcolm C. Pike

  13. Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA

    Anna H. Wu

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  1. Joellen M. Schildkraut
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  2. Lauren C. Peres
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  3. Traci N. Bethea
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  4. Fabian Camacho
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  5. Deanna Chyn
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  6. Emily K. Cloyd
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  7. Elisa V. Bandera
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  8. Alicia Beeghly-Fadiel
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  9. Loren Lipworth
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  10. Charlotte E. Joslin
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  11. Faith G. Davis
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  12. Patricia G. Moorman
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  13. Evan Myers
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  14. Heather M. Ochs-Balcom
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  15. Veronica Wendy Setiawan
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  16. Malcolm C. Pike
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  17. Anna H. Wu
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  18. Lynn Rosenberg
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Corresponding author

Correspondence to Joellen M. Schildkraut.

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Conflict of interest

Patricia Moorman has received compensation for work related to litigation in regard to talc and ovarian cancer.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Schildkraut, J.M., Peres, L.C., Bethea, T.N. et al. Ovarian Cancer in Women of African Ancestry (OCWAA) consortium: a resource of harmonized data from eight epidemiologic studies of African American and white women. Cancer Causes Control 30, 967–978 (2019). https://doi.org/10.1007/s10552-019-01199-7

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  • DOI: https://doi.org/10.1007/s10552-019-01199-7

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