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Determinants of prolactin in postmenopausal Chinese women in Singapore

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Abstract

Purpose

Mechanistic and observational data together support a role for prolactin in breast cancer development. Determinants of prolactin in Asian populations have not been meaningfully explored, despite the lower risk of breast cancer in Asian populations.

Methods

Determinants of plasma prolactin were evaluated in 442 postmenopausal women enrolled in the Singapore Chinese Health Study, a population-based prospective cohort study. At baseline all cohort members completed an in-person interview that elicited information on diet, menstrual and reproductive history, and lifestyle factors. One year after cohort initiation we began collecting blood samples. Quantified were plasma concentrations of prolactin, estrone, estradiol, testosterone, androstenedione, and sex hormone-binding globulin (SHBG). Analysis of covariance method was used for statistical analyses with age at blood draw, time since last meal, and time at blood draw as covariates.

Results

Mean prolactin levels were 25.1% lower with older age at menarche (p value = 0.001), and 27.6% higher with greater years between menarche and menopause (p value = 0.009). Prolactin levels were also positively associated with increased sleep duration (p value = 0.005). The independent determinants of prolactin were years from menarche to menopause, hours of sleep, and the plasma hormones estrone and SHBG (all p values < 0.01).

Conclusion

The role of prolactin in breast cancer development may involve reproductive and lifestyle factors, such as a longer duration of menstrual cycling and sleep patterns.

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Acknowledgments

We thank Ms. Siew Hong Low of the National University of Singapore for supervising the field work of the Singapore Chinese Health Study. Dr. Katz was a post-doctoral fellow in the Translational Research Training in Cancer Etiology and Prevention Program funded by National Cancer Institute (T32 CA186873).

Funding

This study was funded through grants from the US National Institutes of Health: T32 CA186873, R01 CA144034, UM1 CA182876, and R01 CA160746.

Author information

Authors and Affiliations

  1. Department of Pharmacology and Chemical Biology, Women’s Cancer Research Center, Magee Women’s Research Institute, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA

    Tiffany A. Katz & Steffi Oesterreich

  2. Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA

    Anna H. Wu

  3. Department of Urology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA

    Frank Z. Stanczyk

  4. Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA

    Renwei Wang, Jian-Min Yuan & Lesley M. Butler

  5. Duke-NUS Medical School, Singapore, Singapore

    Woon-Puay Koh

  6. Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore

    Woon-Puay Koh

  7. Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA

    Jian-Min Yuan & Lesley M. Butler

  8. Department of Molecular and Cellular Biology, The Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX, USA

    Tiffany A. Katz

Authors
  1. Tiffany A. Katz
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  2. Anna H. Wu
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  3. Frank Z. Stanczyk
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  4. Renwei Wang
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  5. Woon-Puay Koh
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  6. Jian-Min Yuan
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  7. Steffi Oesterreich
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  8. Lesley M. Butler
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Correspondence to Lesley M. Butler.

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Katz, T.A., Wu, A.H., Stanczyk, F.Z. et al. Determinants of prolactin in postmenopausal Chinese women in Singapore. Cancer Causes Control 29, 51–62 (2018). https://doi.org/10.1007/s10552-017-0978-8

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  • DOI: https://doi.org/10.1007/s10552-017-0978-8

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