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Parental smoking, maternal alcohol, coffee and tea consumption and the risk of childhood brain tumours: the ESTELLE and ESCALE studies (SFCE, France)

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Abstract

Purpose

To investigate whether parental smoking around the time of pregnancy or maternal consumption of beverages (alcohol, coffee, or tea) during pregnancy were associated with the risk of CBT.

Methods

We pooled data from two French national population-based case–control studies with similar designs conducted in 2003–2004 and 2010–2011. The mothers of 510 CBT cases (directly recruited from the national childhood cancer register) and 3,102 controls aged under 15 years, frequency matched by age and gender, were interviewed through telephone, which included questions about prenatal parental smoking and maternal consumption of alcohol, coffee and tea. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional logistic regression, adjusted for age, sex and study of origin.

Results

No association was seen between CBT and the mother smoking or drinking alcohol, coffee, or tea during the index pregnancy. The OR between CBT and paternal smoking in the year before birth (as reported by the mother) was 1.25 (95% CI 1.03, 1.52) with an OR of 1.09 (0.99, 1.19) for every 10 cigarettes per day (CPD) smoked. The association between paternal smoking and CBT appeared to be stronger in children diagnosed before the age of five years (OR 1.52, 95% CI 1.14, 2.02) and for astrocytoma (OR 1.86, 95% CI 1.26, 2.74).

Conclusion

We found some evidence of a weak association between paternal smoking in the year before the child’s birth and CBT, especially astrocytomas. These findings need to be replicated in other samples, using similar classifications of tumour subtypes.

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Abbreviations

CI:

Confidence interval

CBT:

Childhood brain tumour

CPD:

Cigarettes per day

ICCC-3:

International classification of childhood cancer 3rd revision

ICD-O-3:

International classification of disease 3rd edition

NF:

Neurofibromatosis

OR:

Odds ratio

PNET:

Primitive neuroectodermal tumour

RNCE:

Registre National des Cancers de l’Enfant, RNCE (National Registry of Childhood Cancers)

SFCE:

Société Française de lutte contre les Cancers et leucémies de l’Enfant et de l’adolescent (French Society for the fight against childhood and adolescent cancers and leukaemias)

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Acknowledgments

The authors would also like to thank all the Société Française de lutte contre les Cancers de l’Enfant et de l’Adolescent (SFCE) principal investigators: Claire Berger (Centre Hospitalier Universitaire, Saint-Etienne), Christophe Bergeron (Centre Léon Bérard, Lyon), Jean-Louis Bernard (Hôpital La Timone, Marseille), Yves Bertrand (Hôpital Debrousse, Lyon), Pierre Bordigoni (Centre Hospitalier Universitaire, Nancy), Patrick Boutard (Centre Hospitalier Régional Universitaire, Caen), Pascal Chastagner (Centre Hospitalier Universitaire, Nancy), Philippe Colombat (Centre Gatien de Clocheville, Tours), Gérard Couillault (Hôpital d’Enfants, Dijon), Anne-Sophie Defachelles (Oscar Lambret Comprehensive Cancer Center, Lille), François Demeocq (Hôpital Hôtel-Dieu, Clermont-Ferrand), Alain Fischer (Hôpital des Enfants Malades, Paris), Virginie Gandemer (Centre Hospitalier Universitaire – Hôpital Sud, Rennes), Stéphanie Haouy (Hôpital Arnaud de Villeneuve, Montpellier), Jean-Pierre Lamagnere (Centre Gatien de Clocheville, Tours), Françoise Lapierre (Centre Hospitalier Universitaire Jean Bernard, Poitiers), Patrick Lutz (Hôpital de Hautepierre, Strasbourg), Geneviève Margueritte (Hôpital Arnaud de Villeneuve, Montpellier), Françoise Mechinaud (Hôpital Mère et Enfants, Nantes), Gérard Michel (Hôpital La Timone, Marseille), Jean Michon (Institut Curie, Paris),Frédéric Millot (Centre Hospitalier Universitaire Jean Bernard, Poitiers), Philippe le Moine (Hôpital Morvan, Brest), Martine Münzer (American Memorial Hospital, Reims), Brigitte Nelken (Hôpital Jeanne de Flandre, Lille), Brigitte Pautard (Centre Hospitalier Universitaire, Amiens), Yves Perel (Hôpital Pellegrin Tripode, Bordeaux), Alain Pierre-Kahn (Hôpital Enfants Malades, Paris), Christophe Piguet (Centre Hospitalier Régional Universitaire, Limoges, Dominique Plantaz (Centre Hospitalier Universitaire, Grenoble), Emmanuel Plouvier (Centre Hospitalier Régional, Besançon), Marilyne Poiree (Fondation Lenval, Nice), Xavier Rialland (Centre Hospitalier Universitaire, Angers), Alain Robert (Hôpital des Enfants, Toulouse), Hervé Rubie (Hôpital des Enfants, Toulouse), Christian Sainte Rose (Centre Hospitalier Universitaire Necker, Paris), Nicolas Sirvent (Hôpital Arnaud de Villeneuve, Montpellier), Christine Soler (Fondation Lenval, Nice), Dominique Valteau-Couanet (Gustave Roussy, Villejuif), and Jean-Pierre Vannier (Hôpital Charles Nicolle, Rouen). The authors thank all families for their generous participation.

Funding

The ESCALE and ESTELLE studies were supported by Grants from INSERM, the Ligue Nationale Contre le Cancer, the Fondation de France, the Fondation ARC pour la Recherche sur le Cancer, the Agence Française de Sécurité Sanitaire des Produits de Santé (ANSM), the Agence Française de Sécurité Sanitaire de l’Environnement et du Travail (ANSES), the association Cent pour sang la vie, the association Enfants cancer et santé, the Institut National du Cancer (INCa), the Agence Nationale de la Recherche (ANR), the Cancéropôle Ile de France.

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Authors and Affiliations

  1. INSERM, Université Paris-Descartes, Université Sorbonne-Paris-Cité, CRESS-EPICEA Epidémiologie des cancers de l’enfant et de l’adolescent, 16 avenue Paul Vaillant Couturier - Bat 15/16, Villejuif Cedex, 94807, Paris, France

    Helen D. Bailey, Brigitte Lacour, Laurent Orsi & Jacqueline Clavel

  2. RNCE - National Registry of Childhood Cancers, Inserm, Villejuif and CHU de Nancy, Villejuif, France

    Brigitte Lacour & Jacqueline Clavel

  3. Département de cancérologie de l’enfant et de l’adolescent, Gustave Roussy, Villejuif, France

    Léa Guerrini-Rousseau

  4. Unité d’ Hémato-Immuno-Oncologie pédiatrique, Pôle Pédiatrique, CHU Toulouse, Toulouse, France

    Anne-Isabelle Bertozzi

  5. Pediatric Oncology Unit, Oscar Lambret Comprehensive Cancer Center, Lille, France

    Pierre Leblond

  6. Institut d’hématologie et d’oncologie pédiatrique, IHOPe, Centre Léon Bérard, Lyon, France

    Cécile Faure-Conter

  7. Hématologie Oncologie et Immunologie pédiatrique, Inserm UMR U1232, CHU d’Angers, Angers, France

    Isabelle Pellier

  8. Clinique de pédiatrie, Hôpital Couple Enfant, CHU Grenoble-Alpes, Grenoble, France

    Claire Freycon

  9. Département de Pédiatrie -Adolescents et Jeunes Adultes, Institut Curie, et Université Paris Descartes, Paris, Paris, France

    François Doz

  10. Service de neurochirurgie pédiatrique, Hôpital Necker-Enfants malades, Université Paris Descartes, Sorbonne Paris Cité, Paris, France

    Stéphanie Puget

  11. Service d’onco-hématologie pédiatrique, Hôpital Pellegrin Tripode, Bordeaux, France

    Stéphane Ducassou

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  1. Helen D. Bailey
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  2. Brigitte Lacour
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  3. Léa Guerrini-Rousseau
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  4. Anne-Isabelle Bertozzi
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  7. Isabelle Pellier
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  8. Claire Freycon
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  9. François Doz
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  11. Stéphane Ducassou
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  12. Laurent Orsi
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  13. Jacqueline Clavel
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Correspondence to Helen D. Bailey.

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Bailey, H.D., Lacour, B., Guerrini-Rousseau, L. et al. Parental smoking, maternal alcohol, coffee and tea consumption and the risk of childhood brain tumours: the ESTELLE and ESCALE studies (SFCE, France). Cancer Causes Control 28, 719–732 (2017). https://doi.org/10.1007/s10552-017-0900-4

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