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Predictors of survival for breast cancer patients with a BRCA1 mutation

  • Epidemiology
  • Published:
Breast Cancer Research and Treatment Aims and scope Submit manuscript

Abstract

Purpose

To evaluate in a contemporary cohort the impacts of chemotherapy and oophorectomy on survival for breast cancer patients with a BRCA1 mutation.

Experimental design

We reviewed the pathology reports and medical records of 372 women with breast cancer and a BRCA1 mutation, diagnosed from 2005 to 2017, between the ages of 25 and 65 and followed them for death from all causes and death from breast cancer. Death was ascertained through the Poland vital statistics registry. We performed survival analysis to evaluate the impacts of chemotherapy (including neoadjuvant cisplatinum) and of oophorectomy on survival.

Results

After a mean follow-up of 5.6 years (median 5.2), 66 of the 372 women died; 56 of the deaths were from breast cancer and 6 were from ovarian cancer. 127 women received neoadjuvant cisplatinum and 245 women received other chemotherapies. Cisplatinum (versus all other therapies) was associated with a hazard ratio of 0.42 (95%CI 0.20–0.87) on breast cancer-specific survival. The 10-year actuarial all-cause survival for women who had both cisplatinum and an oophorectomy was 94.4%. The 10-year all-cause survival for women who had neither cisplatinum nor an oophorectomy was 65.4% (p < 0.01).

Conclusions

Cisplatinum and oophorectomy are effective therapies for women with breast cancer and a BRCA1 mutation.

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Acknowledgements

We thank Ewa Putresza for excellent technical support. We thank the Peter Gilgan Foundation Tour de Bleu and Estée Lauder Companies for their generous support of this project.

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Authors and Affiliations

  1. Women’s College Research Institute, University of Toronto, 76 Grenville Avenue, Toronto, ON, M5S 1B2, Canada

    Steven A. Narod & Ping Sun

  2. International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland

    Tomasz Huzarski, Jacek Gronwald, Tomasz Byrski, Cezary Cybulski & Jan Lubinski

  3. Marie Sklodowska Clinic, Curie Memorial Institute, Krakow, Poland

    Elzbieta Marczyk

  4. Department of Clinical Oncology, Tadeusz Koszarowski Regional Oncology Center, Opole, Poland

    Marek Szwiec

  5. Department of Clinical Oncology, Regional Oncology Center, Bielsko-Biala, Poland

    Rafal Wisniowski

  6. Department of Molecular Medicine, Pomeranian Medical University, Szczecin, Poland

    Bozena Birkenfeld

  7. Counselling Unit, Regional Oncology Center, Świdnica, Poland

    Ewa Kilar

  8. Oncology Diagnostic Center, Zielona Góra, Poland

    Robert Sibilski

Authors
  1. Steven A. Narod
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  2. Tomasz Huzarski
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  11. Robert Sibilski
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  12. Ping Sun
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  13. Jan Lubinski
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Corresponding author

Correspondence to Steven A. Narod.

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The authors have no conflicts of interest to declare.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Narod, S.A., Huzarski, T., Gronwald, J. et al. Predictors of survival for breast cancer patients with a BRCA1 mutation. Breast Cancer Res Treat 168, 513–521 (2018). https://doi.org/10.1007/s10549-017-4605-x

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  • DOI: https://doi.org/10.1007/s10549-017-4605-x

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