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A comparison of toxicity profiles between the lower and standard dose capecitabine in breast cancer: a systematic review and meta-analysis

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Abstract

Capecitabine 1000 mg/m2 bid × 14 days every 21 days (14/21) has been reported to have similar efficacy but more favorable toxicity profile than the approved dosage of 1250 mg/m2. However, a dose-toxicity relationship of capecitabine in breast cancer patients has not been fully elucidated. We performed a systematic review and meta-analysis to compare a safety profile between capecitabine starting dose of 1000 and 1250 mg/m2 bid. Studies were identified using PubMed, ASCO, and San Antonio Breast Cancer Symposium abstract databases through December 2015. Eligible trials included phase II/III trials of capecitabine monotherapy at 1000 or 1250 mg/m2 bid (14/21) for breast cancer patients that reported adequate safety data for all (grade 1–4) or high (grade 3–4) grade hand foot syndrome (HFS), diarrhea, fatigue, nausea, vomiting, stomatitis, neutropenia, thrombocytopenia, or anemia, as well as dose reductions, treatment discontinuation or treatment-related deaths. The summary incidence was calculated using random-effects models. A total of 4833 patients from 34 trials were included. 1218 and 3615 patients were treated with capecitabine 1000 and 1250 mg/m2 bid, respectively. A significantly lower incidence of dose reduction (15.9 vs. 39.0 %; P = 0.007), high-grade HFS (12.0 vs. 19.0 %; P = 0.01), diarrhea (5.3 vs. 9.1 %; P = 0.01), and neutropenia (1.8 vs. 7.3 %; P < 0.01), and all-grade neutropenia (5.8 vs. 25.4 %; P = 0.01) was seen in capecitabine 1000 mg/m2 compared to 1250 mg/m2. Capecitabine monotherapy at 1000 mg/m2 bid (14/21) has a clinically meaningful and significantly better toxicity profile compared to 1250 mg/m2 bid (14/21).

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Authors’ contributions

TFN involved in study concept and design, acquisition of data, statistical analysis and interpretation of data, drafting of the manuscript. MS involved in acquisition of data and critical revision of the manuscript. HBM participated in the elaboration of the research design and made important contributions in revising the manuscript.

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Authors and Affiliations

  1. UNC Lineberger Comprehensive Cancer Center, 170 Manning Drive, Campus Box 7305, Chapel Hill, NC, 27599, USA

    Tomohiro F. Nishijima & Hyman B. Muss

  2. Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA

    Maya Suzuki

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  1. Tomohiro F. Nishijima
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Correspondence to Tomohiro F. Nishijima.

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Dr. Muss has held consultant/advisory role for Pfizer and HarborPath. The remaining authors state that they have no conflict on interests.

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Nishijima, T.F., Suzuki, M. & Muss, H.B. A comparison of toxicity profiles between the lower and standard dose capecitabine in breast cancer: a systematic review and meta-analysis. Breast Cancer Res Treat 156, 227–236 (2016). https://doi.org/10.1007/s10549-016-3756-5

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