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Second primary breast cancer in BRCA1 and BRCA2 mutation carriers: 10-year cumulative incidence in the Breast Cancer Family Registry

  • Epidemiology
  • Published:
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Abstract

BReast CAncer genes 1 and 2 (BRCA1 and BRCA2) mutation carriers diagnosed with breast cancer are at increased risk of developing a second primary breast cancer. Data from high-risk clinics may be subject to different biases which can cause both over and underestimation of this risk. Using data from a large multi-institutional family registry we estimated the 10-year cumulative risk of second primary breast cancer including more complete testing information on family members. We prospectively followed 800 women diagnosed with breast cancer from the Breast Cancer Family Registry (BCFR) who were carriers of a BRCA1 or BRCA2 pathogenic mutation or a variant of unknown clinical significance. In order to limit survival and ascertainment bias, cases were limited to those diagnosed with a first primary breast cancer from 1994 to 2001 and enrolled in the BCFR within 3 years after their cancer diagnosis. We excluded women enrolled after being diagnosed with a second breast cancer. We calculated 10-year incidence of second primary breast cancers. The 10-year incidence of a second primary breast cancer was highest in BRCA1 mutation carriers (17 %; 95 % CI 11–25 %), with even higher estimates in those first diagnosed under the age of 40 (21 %; 95 % CI 13–34 %). Lower rates were found in BRCA2 mutation carriers (7 %; 95 % CI 3–15 %) and women with a variant of unknown clinical significance (6 %; 95 % CI 4–9 %). Whereas the cumulative 10-year incidence of second primary breast cancer is high in BRCA1 mutation carriers, the estimates in BRCA2 mutation carriers and women with variants of unknown clinical significance are similar to those reported in women with sporadic breast cancer.

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Acknowledgments

This work was supported by grant UM1 CA164920 from the USA National Cancer Institute. The content of this manuscript does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating centers in the Breast Cancer Family Registry (BCFR), nor does mention of trade names, commercial products, or organizations imply endorsement by the USA Government or the BCFR.

Conflict of interest

Dr. Chung has stock ownership and consulting role in Bioreference Laboratories.

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Authors and Affiliations

  1. Department of Surgery, Tel Aviv Sourasky Medical Center, 6 Weizman St, Tel Aviv, Israel

    Tehillah S. Menes

  2. Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

    Tehillah S. Menes

  3. Department of Epidemiology, Mailman School of Public Health, New York, NY, USA

    Mary Beth Terry & Yuyan Liao

  4. Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA

    Mary Beth Terry

  5. Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA

    David Goldgar

  6. Department of Molecular Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada

    Irene L. Andrulis

  7. Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada

    Julia A. Knight

  8. Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada

    Julia A. Knight

  9. Cancer Prevention Institute of California, Fremont, CA, USA

    Esther M. John

  10. Division of Epidemiology, Department of Health Research and Policy, and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA

    Esther M. John

  11. Department of Pathology, The University of Melbourne, Melbourne, Australia

    Melissa Southey

  12. Department of Genetics and Genome Sciences, Case Western Reserve University Medical School, Cleveland, OH, USA

    Alexander Miron

  13. Department of Pediatrics and Medicine, Columbia University, New York, NY, USA

    Wendy Chung

  14. Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, UT, USA

    Saundra S. Buys

Authors
  1. Tehillah S. Menes
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  2. Mary Beth Terry
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  3. David Goldgar
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  4. Irene L. Andrulis
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  5. Julia A. Knight
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  6. Esther M. John
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  7. Yuyan Liao
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  8. Melissa Southey
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  9. Alexander Miron
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  10. Wendy Chung
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  11. Saundra S. Buys
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Corresponding author

Correspondence to Tehillah S. Menes.

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Menes, T.S., Terry, M.B., Goldgar, D. et al. Second primary breast cancer in BRCA1 and BRCA2 mutation carriers: 10-year cumulative incidence in the Breast Cancer Family Registry. Breast Cancer Res Treat 151, 653–660 (2015). https://doi.org/10.1007/s10549-015-3419-y

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  • DOI: https://doi.org/10.1007/s10549-015-3419-y

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