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Biosensors for detection of prostate cancer: a review

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Abstract

Diagnosis of prostate cancer (PC) has posed a challenge worldwide due to the sophisticated and costly diagnostics tools, which include DRE, TRUS, GSU, PET/CT scan, MRI, and biopsy. These diagnostic techniques are very helpful in the detection of PCs; however, all the techniques have their serious limitations. Biosensors are easier to fabricate and do not require any cutting-edge technology as required for other imaging techniques. In this regard, point-of-care (POC) biosensors are important due to their portability, convenience, low cost, and fast procedure. This review explains the various existing diagnostic tools for the detection of PCs and the limitation of these methods. It also focuses on the recent studies on biosensors technologies as an alternative to the conventional diagnostic techniques for the detection of PCs.

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Abbreviations

PC:

Prostate cancer

DRE:

Digital rectal examination

TRUS:

Transrectal Ultrasound

GSU:

Gray-scale ultrasonography

PET/CT:

Positron emission tomography/computer tomography scan

PDU:

Power doppler ultrasonography

3D-CE-PDU:

Three-dimensional contrast-enhanced power doppler ultrasonography

TMRI:

Transrectal magnetic resonance imaging

PSA:

Prostate-specific antigen

ELISA:

Enzyme-linked immunosorbent assay

SPE:

Screen-printed electrodes

LOD:

Limit of detection

VEGF:

Vascular endothelial growth factor

MEMS:

Micro-electromechanical systems

SPR:

Surface plasmon resonance

QD:

Quantum dot

LSPR:

Localized surface plasmon resonance

QCM:

Quartz crystal microbalance

PZT:

Lead titanate zirconate

LFA:

Lateral flow assay

µPAD:

Microfluidic paper-based analytical devices

POC:

Point- of- care

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Acknowledgment

We sincerely acknowledge the generous funding received from the Department of Biotechnology, India (No. BT/PR24652/NER/95/795/2017; Dated: 06/03/2019), sanctioned to Dr. Manashjit Gogoi for carrying out this piece of work. Also SERB, Govt of India is acknowledged for SERB project (No. EMR/2016/002634) sanctioned to Dr. Mrityunjoy Mahato.

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Authors and Affiliations

  1. Department of Biomedical Engineering, North-Eastern Hill University, Shillong, 793022, Meghalaya, India

    Sourav Sarkar & Manashjit Gogoi

  2. Physics Division, Department of Basic Sciences and Social Sciences, North-Eastern Hill University, Shillong, 793022, Meghalaya, India

    Mrityunjoy Mahato

  3. Biosciences and Biomedical Engineering, Indian Institute of Technology, Indore-453552, Madhya Pradesh, India

    Abhijeet Balwantrao Joshi & Prashant Kodgire

  4. Department of General Surgery, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India

    Arup Jyoti Baruah

  5. Department of Biochemistry, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong-793018, Meghalaya, India

    Polina Boruah

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  1. Sourav Sarkar
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Sarkar, S., Gogoi, M., Mahato, M. et al. Biosensors for detection of prostate cancer: a review. Biomed Microdevices 24, 32 (2022). https://doi.org/10.1007/s10544-022-00631-1

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