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Effects of two surface acoustic wave sorting chips on particles multi-level sorting

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Abstract

Particle/cell sorting has great potential in medical diagnosis and chemical analysis. Two kinds of microfluidic sorting chips (sequential sorting chip and direct sorting chip) are designed, which combine hydraulic force and acoustic radiation force to achieve continuous sorting of multiple particles. Firstly, the optimal values of the angle (α) between the interdigital transducer (IDT) and the main channel, the peak-to-peak voltage (Vpp), the main flow velocity (Vmax) and the flow ratio (A) are determined by simulation and experiments, the related optimal parameters were obtained that the α = 15°, Vpp = 25 V, Vmax = 4 mm/s, flow ratio A1 = 0.2, and A2 = 0.5, respectively. Then, the corresponding sorting experiments were carried out using two kinds of sorting chips to sort the polystyrene (PS) particles with diameters of 1 μm, 5 μm, and 10 μm, and the sorting rate and purity of particles were calculated and analyzed. Experimental results show that the two kinds of sorting chips can achieve continuous sorting of multiple particles, and the sorting effect of sequential sorting chip (control flow ratio) is better than that of direct sorting chip. In addition, the sorting chips in our research have the advantages of simple structure, high sorting efficiency, and the ability to sort multiple particles, which can be applied in medical and chemical research fields, such as cell sorting and chemical analysis.

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Acknowledgments

Financial support from the Jilin Province Natural Science Foundation Projects (No. 20170101136JC), the National Natural Science Foundation Projects (No. 51375207; 51875234), and the Jilin Provincial Department of Education Project (JJKH20190140KJ) are gratefully acknowledged.

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Authors and Affiliations

  1. College of Mechanical and Aerospace Engineering, Jilin University, Changchun, 130025, China

    Guojun Liu, Fang He, Huajie Tang, Zhiqiang Li, Zhigang Yang & Yanyan Zhang

  2. Emergency Department, China-Japan Union Hospital of Jilin University, Changchun, China

    Yan Li

  3. Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun, China

    Hong Zhao

  4. College of Communication Engineering, Jilin University, Changchun, 130025, China

    Xinbo Li

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  1. Guojun Liu
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  2. Fang He
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  3. Yan Li
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  4. Hong Zhao
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  5. Xinbo Li
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  6. Huajie Tang
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  7. Zhiqiang Li
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Correspondence to Hong Zhao.

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Liu, G., He, F., Li, Y. et al. Effects of two surface acoustic wave sorting chips on particles multi-level sorting. Biomed Microdevices 21, 59 (2019). https://doi.org/10.1007/s10544-019-0419-4

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  • DOI: https://doi.org/10.1007/s10544-019-0419-4

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