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Fabrication of sponge-forming microneedle patch for rapidly sampling interstitial fluid for analysis

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Abstract

Microneedle (MN) patch has been used for collecting dermal interstitial fluid (ISF) containing biomarkers from patients with safety, pain-free and easy-to-use manner. However, long sampling time for biomarkers analysis still poses a significant challenge. Here, we describe a new sponge-forming MN patch consisting of polyvinyl formal (PVF) for rapidly extracting ISF from skin. Owing to the supreme water affinity of PVF, this MN patch can extract 1.6 mg ISF in 1 min without the assistance of extra devices, which remarkably facilitates timely analysis. The MN patch had preserved structural integrity in the swelling hydrated state without leaving residues in skin after usage, and the treated skin recovered within 8 h. More importantly, the extracted ISF can be efficiently recovered from the MN patch by simple centrifugation for the subsequent offline analysis of biomarkers such as glucose and cholesterol. Our results reveal that the new sponge-forming MN patch holds considerable promise for minimally invasive sampling ISF for biomarkers detection in real-life situations.

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Acknowledgements

This work was supported by the Natural Science Foundation of Fujian Province (Grant No.2019 J01806), the Education Department of Fujian Province (Grant No. JZ160470), the Putian Science and Technology Bureau (Grant No. 2018SP3004) and Training Program of Innovation and Entrepreneurship for Undergraduates (Grant No. 201811498003 and 201811498027).

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Authors and Affiliations

  1. School of Pharmacy and Medical Technology, Putian University, Fujian, 351100, China

    Jianmin Chen, Meixia Wang, Yaling Ye, Zhouyan Yang, Zhipeng Ruan & Nan Jin

  2. Key Laboratory of Pharmaceutical Analysis and Laboratory Medicine (Putian University), Fujian Province University, Fujian, China

    Jianmin Chen, Zhipeng Ruan & Nan Jin

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  1. Jianmin Chen
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  2. Meixia Wang
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  3. Yaling Ye
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  4. Zhouyan Yang
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  5. Zhipeng Ruan
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Correspondence to Jianmin Chen.

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Chen, J., Wang, M., Ye, Y. et al. Fabrication of sponge-forming microneedle patch for rapidly sampling interstitial fluid for analysis. Biomed Microdevices 21, 63 (2019). https://doi.org/10.1007/s10544-019-0413-x

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