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Interventional magnetic resonance imaging guided carotid embolectomy using a novel resonant marker catheter: demonstration of preclinical feasibility

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Abstract

To assess the visualization and efficacy of a wireless resonant circuit (wRC) catheter system for carotid artery occlusion and embolectomy under real-time MRI guidance in vivo, and to compare MR imaging modality with x-ray for analysis of qualitative physiological measures of blood flow at baseline and after embolectomy. The wRC catheter system was constructed using a MR compatible PEEK fiber braided catheter (Penumbra, Inc, Alameda, CA) with a single insulated longitudinal copper loop soldered to a printed circuit board embedded within the catheter wall. In concordance with IACUC protocol (AN103047), in vivo carotid artery navigation and embolectomy were performed in four farm pigs (40–45 kg) under real-time MRI at 1.5T. Industry standard clots were introduced in incremental amounts until adequate arterial occlusion was noted in a total of n=13 arteries. Baseline vasculature and restoration of blood flow were confirmed via MR and x-ray imaging, and graded by the Thrombolysis in Cerebral Infarction (TICI) scale. Wilcoxon signed-rank tests were used to analyze differences in recanalization status between DSA and MRA imaging. Successful recanalizations (TICI 2b/3) were compared to clinical rates reported in literature via binomial tests. The wRC catheter system was visible both on 5° sagittal bSSFP and coronal GRE sequence. Successful recanalization was demonstrated in 11 of 13 occluded arteries by DSA analysis and 8 of 13 by MRA. Recanalization rates based on DSA (0.85) and MRA (0.62) were not significantly different from the clinical rate of mechanical aspiration thrombectomy reported in literature. Lastly, a Wilcoxon signed rank test indicated no significant difference between TICI scores analyzed by DSA and MRA. With demonstrated compatibility and visualization under MRI, the wRC catheter system is effective for in vivo endovascular embolectomy, suggesting progress towards clinical endovascular interventional MRI.

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Acknowledgements

This work was supported by the National Institute of Biomedical Imaging and Bioengineering grants R01EB012031 and R21EB020283 and the National Center for Advancing Translational Sciences grant UL1TR000004. The authors thank Penumbra, Inc., for in-kind provision of catheter shafts, materials, and engineering expertise.

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  1. Jeffrey K. Yang, Andre M. Cote and Caroline D. Jordan contributed equally to this work.

Authors and Affiliations

  1. Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, USA

    Jeffrey K. Yang, Andre M. Cote, Caroline D. Jordan, Aaron D. Losey, David McCoy, Jay F. Yu, Teri Moore, Carol Stillson, Fabio Settecase, Matthew D. Alexander, Andrew Nicholson, Daniel L. Cooke, Maythem Saeed, Alastair J. Martin, Mark W. Wilson & Steven W. Hetts

  2. Penumbra, Inc, Alameda, CA, USA

    Andrew Chu & Dave Barry

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  1. Jeffrey K. Yang
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Yang, J.K., Cote, A.M., Jordan, C.D. et al. Interventional magnetic resonance imaging guided carotid embolectomy using a novel resonant marker catheter: demonstration of preclinical feasibility. Biomed Microdevices 19, 88 (2017). https://doi.org/10.1007/s10544-017-0225-9

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