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Polymer-based interconnection cables to integrate with flexible penetrating microelectrode arrays

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A Correction to this article was published on 02 November 2017

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Abstract

There have been various types of interconnection methods for neural interfacing electrodes, such as silicon ribbon cables, wire bonding and polymer-based cables. In this study, interconnection cables were developed for integration with a Flexible Penetrating Microelectrode Array (FPMA) that was previously developed for neural signal recording or stimulation. Polyimide and parylene C were selected as base materials for the interconnection cables as both materials can preserve the flexibility of the FPMA better than other interconnection methods such as silicon ribbon cable or wire bonding. We conducted durability tests to determine if the interconnection cables were suitable for in-vivo implantation, by long-term soaking of the cables in phosphate buffered saline solution. We measured the changes in impedance over time, and equivalent circuit models were used to analyze the electrochemical phenomena on the surface of the cables. Lastly, we implanted the cable-integrated electrodes device onto rabbit’s sciatic nerve and recorded neural signals to prove the feasibility of the developed FPMA integration system.

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Change history

  • 02 November 2017

    The original version of this article unfortunately contained a mistake. In Eqs. (1) to (3), the gas constant ‘R’ should be replaced with Boltzmann constant ‘k B.’ This change accompanies the change in the paragraph following Eq. (3) as below:

References

  • M.R. Abidian, D.C. Martin, Experimental and theoretical characterization of implantable neural microelectrodes modified with conducting polymer nanotubes. Biomaterials 29, 1273–1283 (2008)

    Article  Google Scholar 

  • R. Bhandari, S. Negi, R. Van Wagenen, F. Solzbacher, Parylene C-based flexible interface for neuroprosthetic applications. Proc. Electron Compon Technol Conf, 1010–1014 (2010)

  • D. Byun, S.J. Cho, S. Kim, Fabrication of a flexible penetrating microelectrode array for use on curved. J. Micromech. Microeng. 23, 125010 (2013)

    Article  Google Scholar 

  • J.H. Chang, J. Park, Y.K. Pak, J.J. Pak, Fitting improvement using a new electrical circuit model for the electrode-electrolyte interface. Proc. 3rd Int. IEEE EMBS Conf. Neural Eng, 572–574 (2007)

  • M.-Y. Cheng, W.-T. Park, A. Yu, R.-F. Xue, K.L. Tan, D. Yu, S.-H. Lee, C.L. Gan, M. Je, A flexible polyimide cable for implantable neural probe arrays. Microsyst. Technol. 19, 1111–1118 (2013)

    Article  Google Scholar 

  • I.H. Cho, H. Shin, H.J. Lee, I.J. Cho, Effects of fabrication process variation on impedance of neural probe microelectrodes. J. Electr. Eng. Technol. 10, 30–40 (2015)

    Article  Google Scholar 

  • W. Chun, N. Chou, S. Cho, S. Yang, S. Kim, Evaluation of sub-micrometer parylene C films as an insulation layer using electrochemical impedance spectroscopy. Prog. Org. Coatings 77, 537–547 (2014)

    Article  Google Scholar 

  • S.F. Cogan, Neural stimulation and recording electrodes. Annu. Rev. Biomed. Eng. 10, 275–309 (2008)

    Article  Google Scholar 

  • P. Flowers et al., Chemistry, OpenStax, Houston, TX (2015)

  • W. Franks, I. Schenker, P. Schmutz, A. Hierlemann, Impedance characterization and modeling of electrodes for biomedical applications. IEEE Trans. Biomed. Eng. 52, 1295–1302 (2005)

    Article  Google Scholar 

  • M. Ghosh, Polyimides: Fundamentals and Applications, CRC Press, Boca Raton, FL (1996)

  • D.W.L. Hukins, A. Mahomed, S.N. Kukureka, Accelerated aging for testing polymeric biomaterials and medical devices. Med. Eng. Phys. 30, 1270–1274 (2008)

    Article  Google Scholar 

  • K.E. Jones, P.K. Campbell, R.A. Normann, A glass/silicon composite intracortical electrode array. Ann. Biomed. Eng. 20, 423–437 (1992)

    Article  Google Scholar 

  • S. Kisban, S. Herwik, K. Seidl, B. Rubehn, A. Jezzini, M.A. Umiltà, L. Fogassi, T. Stieglitz, O. Paul, P. Ruther, Microprobe array with low impedance electrodes and highly flexible polyimide cables for acute neural recording. Proc. Annu. Int. Conf. IEEE Eng. Med. Biol, 175–178 (2007)

  • C.D. Lee, E. Meng, Mechanical properties of thin-film Parylene–metal–Parylene devices. Frontiers in Mechanical Engineering 1, 10 (2015)

  • W. Li, D.C. Rodger, E. Meng, J.D. Weiland, M.S. Humayun, Y.C. Tai, Wafer-level parylene packaging with integrated rf electronics for wireless retinal prostheses. J. Microelectromech. Syst. 19, 735–742 (2010)

    Article  Google Scholar 

  • P.R. Menon, W. Li, A. Tooker, Y.C. Tai, Characterization of water vapor permeation through thin film parylene C. Proc. 15th Int. Conf. Solid-State Sensors, Actuators Microsystems, 1892–1895 (2009)

  • R.P. Metzen, T. Stieglitz, The effects of annealing on mechanical, chemical, and physical properties and structural stability of Parylene C. Biomed Microdevices 15, 727-735 (2013)

  • J.U. Meyer, T. Stieglitz, O. Scholz, W. Haberer, H. Beutel, High density interconnects and flexible hybrid assemblies for active biomedical implants. IEEE Trans. Adv. Packag. 24, 366–374 (2001)

    Article  Google Scholar 

  • S. Musallam, M.J. Bak, P.R. Troyk, R.A. Andersen, A floating metal microelectrode array for chronic implantation. J. Neurosci. Methods 160, 122–127 (2007)

    Article  Google Scholar 

  • C.T. Nordhausen, E.M. Maynard, R.A. Normann, Single unit recording capabilities of a 100 microelectrode array. Brain Res. 726, 129–140 (1996)

    Article  Google Scholar 

  • S.J. Park, Y.J. Lee, D.N. Heo, I.K. Kwon, K.-S. Yun, J.Y. Kang, S.H. Lee, Functional nerve cuff electrode with controllable anti-inflammatory drug loading and release by biodegradable nanofibers and hydrogel deposition. Sensors Actuators B Chem. 215, 133–141 (2015)

    Article  Google Scholar 

  • P.J. Rousche, D.S. Pellinen, D.P. Pivin, J.C. Williams, R.J. Vetter, D.R. Kipke, Flexible polyimide-based intracortical electrode arrays with bioactive capability. IEEE Trans. Biomed. Eng. 48, 361–371 (2001)

    Article  Google Scholar 

  • B. Rubehn, T. Stieglitz, In vitro evaluation of the long-term stability of polyimide as a material for neural implants. Biomater. 31, 3449-3458 (2010)

  • K.L. Tan, M.-Y. Cheng, P.G. Teh, W.T. Park, M. Je, Integration of low profile neural probe array with flexible polyimide cable. Proc. 13th Electron. Packag. Technol. Conf, 785–788 (2011)

  • D. Yu, M.-Y. Cheng, L.S. Lim, P. Myo, A. Yu, Newly developed integration method for biomedical implants using flexible polymer cable. Proc. 12th Electron. Packag. Technol. Conf, 388–392 (2010)

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Acknowledgements

This research was supported by grants from the Basic Science Research Program through the National Research Foundation (NRF-2017R1A2B2004598) and DGIST R&D Program (16-BD-0404) funded by the Ministry of Science, ICT & Future Planning, and the Robot Industry Fusion Core Technology Development Project (10052980) through the Korea Evaluation Institute of Industrial Technology funded by the Ministry of Trade, Industry and Energy of Korea.

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Authors and Affiliations

  1. Department of Medical System Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea

    Keonghwan Oh

  2. School of Mechatronics, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea

    Donghak Byun

  3. Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, Republic of Korea

    Sohee Kim

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  1. Keonghwan Oh
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  2. Donghak Byun
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  3. Sohee Kim
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Correspondence to Sohee Kim.

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A correction to this article is available online at https://doi.org/10.1007/s10544-017-0232-x.

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Oh, K., Byun, D. & Kim, S. Polymer-based interconnection cables to integrate with flexible penetrating microelectrode arrays. Biomed Microdevices 19, 76 (2017). https://doi.org/10.1007/s10544-017-0217-9

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