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On the injectability of free-standing magnetic nanofilms

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Abstract

Free-standing films with sub-micrometric thickness, composed of soft polymers and functional nanostructures are promising candidates for many potential applications in the biomedical field, such as reduced port abdominal surgery. In this work, freely suspended poly(L-lactic acid) nanofilms with controlled morphology embedding superparamagnetic iron oxide nanoparticles were fabricated by spin-coating deposition. The mechanical properties of magnetic nanofilms were investigated by Strain-Induced Elastic Buckling Instability for Mechanical Measurements (SIEBIMM) test. Our results show that these freely suspended nanocomposite nanofilms are highly flexible and deformable, with Young’s moduli of few GPa. Since they can be handled in liquid with syringes, a quantitative description of the nanofilms behavior during the manipulation with clinically applicable needles has been also provided. These magnetic nanofilms, remotely controllable by external electromagnetic fields, have potential applications in minimally invasive surgery as injectable nanopatches on inner organs wall.

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Acknowledgement

This work was supported in part by JFE (The Japanese Foundation for Research and Promotion of Endoscopy) Grant (T.F.). JSPS KAKENHI (grant number 15H05355 for T.F., 16K14009 for S.T.) from MEXT, Japan, and the Precursory Research for Embryonic Science and Technology (PRESTO) from the Japan Science and Technology Agency (JST) (grant number JPMJPR152A for T.F.). Nicola M. Pugno is supported by the European Research Council PoC 2015 “Silkene” No. 693670, by the European Commission H2020 under the Graphene Flagship Core 1 No. 696656 (WP14 “Polymer Nanocomposites”) and under the FET Proactive “Neurofibres” No. 732344.

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Author notes

  1. Virginia Pensabene

    Present address: School of Electronic and Electrical Engineering, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK

Authors and Affiliations

  1. Center for MicroBioRobotics IIT@SSSA, Istituto Italiano di Tecnologia, Viale Rinaldo Piaggio 34, 56025, Pontedera, Italy

    Silvia Taccola, Virginia Pensabene & Virgilio Mattoli

  2. School of Medicine, Leeds Institute of Biomedical and Clinical Sciences, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK

    Virginia Pensabene

  3. Waseda Institute for Advanced Study, Waseda University, TWIns, 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo, 162-8480, Japan

    Toshinori Fujie

  4. Japan Science and Technology Agency, PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012, Japan

    Toshinori Fujie

  5. Department of Life Science and Medical Bioscience, Faculty of Science and Engineering, Waseda University, TWIns, 2-2 Wakamtsu-cho, Shinjuku-ku, Tokyo, 162-8480, Japan

    Shinji Takeoka

  6. Laboratory of Bio-Inspired & Graphene Nanomechanics, Department of Civil, Environmental and Mechanical Engineering, University of Trento, Via Mesiano 77, 38123, Trento, Italy

    Nicola M. Pugno

  7. School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, E1 4NS, London, UK

    Nicola M. Pugno

  8. Ket Lab, Edoardo Amaldi Foundation, Italian Space Agency, Via del Politecnico snc, 00133, Rome, Italy

    Nicola M. Pugno

Authors
  1. Silvia Taccola
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  2. Virginia Pensabene
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  3. Toshinori Fujie
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  4. Shinji Takeoka
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  5. Nicola M. Pugno
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  6. Virgilio Mattoli
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Corresponding authors

Correspondence to Silvia Taccola or Virgilio Mattoli.

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Taccola, S., Pensabene, V., Fujie, T. et al. On the injectability of free-standing magnetic nanofilms. Biomed Microdevices 19, 51 (2017). https://doi.org/10.1007/s10544-017-0192-1

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  • DOI: https://doi.org/10.1007/s10544-017-0192-1

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