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RETRACTED ARTICLE: Characterization of a new bacteriocin-like inhibitory peptide produced by Lactobacillus sakei B-RKM 0559

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This article was retracted on 18 January 2024

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Abstract

The biopreservation strategy allows extending the shelf life and food safety through the use of indigenous or controlled microbiota and their antimicrobial compounds. The aim of this work was to characterize an inhibitory substance with bacteriocin-like activity (Sak-59) produced by the potentially probiotic L. sakei strain from artisanal traditional Kazakh horse meat product Kazy. The maximum production of Sak-59 occurred at the stationary phase of the L. sakei growth. Sak-59 showed inhibitory activity against gram-positive meat spoilage bacteria strains of Listeria monocytogenes, Staphylococcus aureus, and pathogenic gram-negative bacteria strains of Serratia marcescens and Escherichia coli, but not against the tested Lactobacilli strains. Sak-59 activity, as measured by diffusion assay in agar wells, was completely suppressed after treatment with proteolytic enzymes and remained stable after treatment with α-amylase and lipase, indicating that Sak-59 is a peptide and most likely not glycosylated or lipidated. It was concluded that Sak-59 is a potential new bacteriocin with a characteristic activity spectrum, which can be useful in the food and feed industries.

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Acknowledgements

We are grateful to Prof. K.Ch. Almagambetov, Prof. A.B. Abzhalelov and Prof. K.D. Zakaria for support of the study. This research was funded by the Science Committee of the Ministry of Education and Science of the Republic of Kazakhstan (Grant No. AP08856679 and Grant No. AP09260001).

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Authors and Affiliations

  1. Laboratory of Genetics and Biochemistry of Microorganisms, Republican Collection of Microorganisms of the Committee of Science of the Ministry of Education and Science of the Republic of Kazakhstan, 13/1 Valikhanov Str., 010000, Nur-Sultan, Republic of Kazakhstan

    Gulyaim K. Abitayeva, Arman S. Abilkhadirov & Serik M. Shaikhin

  2. Laboratory of Biotechnology, Republican Collection of Microorganisms of the Committee of Science of the Ministry of Education and Science of the Republic of Kazakhstan, 13/1 Valikhanov Str., Nur-Sultan, 010000, Republic of Kazakhstan

    Maira S. Urazova

  3. Laboratory of Microbiology, Republican Collection of Microorganisms of the Committee of Science of the Ministry of Education and Science of the Republic of Kazakhstan, 13/1 Valikhanov Str., 010000, Nur-Sultan, Republic of Kazakhstan

    Zinigul S. Sarmurzina

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  1. Gulyaim K. Abitayeva
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  2. Maira S. Urazova
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Contributions

GA, MU, and AA carried out the experiments and analysis of the data. ZS and SSh contributed to the conception and design of the study. All authors contributed to the manuscript revision and approved the submitted version.

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Correspondence to Serik M. Shaikhin.

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Abitayeva, G.K., Urazova, M.S., Abilkhadirov, A.S. et al. RETRACTED ARTICLE: Characterization of a new bacteriocin-like inhibitory peptide produced by Lactobacillus sakei B-RKM 0559. Biotechnol Lett 43, 2243–2257 (2021). https://doi.org/10.1007/s10529-021-03193-z

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