Abstract
Gram-negative bacilli such as Pseudomonas spp., Pseudoalteromonas sp., Angiococcus sp., Archangium sp., Burkholderia spp., Chromobacterium sp., Chondromyces sp., Cystobacter sp., Jahnella sp., Janthinobacterium sp., Lysobacter spp., Paraliomyxa sp., Photobacterium spp., Photorhabdus sp., Pontibacter sp., Ruegeria sp., Serratia sp., Sorangium sp., Sphingomonas sp., and Xenorhabdus spp. produce an enormous array of short peptides of 30 residues or fewer that are potential pharmaceutical drugs and/or biocontrol agents. The need for novel lead antibiotic compounds is urgent due to increasing drug resistance, and this review summarises 150 Gram-negative bacilli-derived compounds reported since 2000, including 40 cyclic lipopeptides from Pseudomonas spp.; nine aromatic peptides; eight glycopeptides; 45 different cyclic lipopeptides; 24 linear lipopeptides; eight thiopeptides; one lasso peptide; ten typical cyclic peptides; and five standard linear peptides. The current and potential therapeutic applications of these peptides, including structures and antituberculotic, anti-cyanobacterial, antifungal, antibacterial, antiviral, insecticidal, and antiprotozoal activities are discussed.
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Acknowledgements
This work was supported by grants from the National Natural Science Foundation of China (NSFC, Nos. 31672530 and U1704117) and the Doctor al Foundation of Henan University of Science and Technology (No. 4022/13480021).
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Structures of Gram-negative bacilli-derived peptide antibiotics are included in the Supplementary material.
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Xue, Y., Wang, M., Zhao, P. et al. Gram-negative bacilli-derived peptide antibiotics developed since 2000. Biotechnol Lett 40, 1271–1287 (2018). https://doi.org/10.1007/s10529-018-2589-1
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DOI: https://doi.org/10.1007/s10529-018-2589-1