Abstract
Aging entails the progressive decline in the body’s self-regulation and functionality over time. Notably, obesity and aging exhibit parallel phenotypes, with obesity further accelerating the aging process across multiple dimensions and diminishing lifespan. In this study, we explored the impact of trans fatty acid (TFA) consumption on the overall health and lifespan of male Drosophila melanogaster under an isocaloric high-sugar and high-fat diet. Our results indicate that TFA intake results in a shortened lifespan, elevated body weight, and increased triglyceride levels in flies fed a high-sugar and high-fat diet with equivalent caloric intake. Additionally, TFA exposure induces oxidative stress, locomotor deficits, and damage to the intestinal barrier in flies. Collectively, chronic TFA consumption expedites the aging process and reduces the lifespan of male Drosophila melanogaster. These results contribute supplementary evidence regarding the adverse health effects associated with TFAs.
Graphical Abstract
Trans fatty acid intake results in a shortened lifespan, elevated body weight, and increased triglyceride levels in male Drosophila melanogaster fed a high-sugar and high-fat diet with equivalent caloric intake. Additionally, Trans fatty acid exposure induces oxidative stress, locomotor deficits, and damage to the intestinal barrier in flies.
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Funding
This work was funded by Basic and Applied Basic Research Foundation of Guangdong Province (Grant no.: 2021B1515140057), National Natural Science Foundation of China (Grant no.: 82273622), BYHEALTH Nutrition and Health Research Foundation (Grant no.: TY202101001), Undergraduate Training Program for Innovation and Entrepreneurship (Grant no.: GDMU2023331), Discipline Construction Project of Guangdong Medical University (Grant no.: 4SG21016G).
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Qianhua Yuan: investigation, data curation, writing—original draft. Mengliu Luo: validation, writing—review and editing. Yutong Xie: investigation, visualization. Wanhan Song: formal analysis. Ya Wang: data curation, validation. Dazhang Deng: writing—review and editing. Shuyan Chen: investigation, writing—review and editing. Honghui Guo: resources, project administration, supervision. All authors have read and approved the submitted version of the paper.
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Yuan, Q., Luo, M., Xie, Y. et al. Chronic trans fatty acid consumption shortens lifespan in male Drosophila melanogaster on a high-sugar and high-fat diet. Biogerontology (2024). https://doi.org/10.1007/s10522-024-10101-1
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DOI: https://doi.org/10.1007/s10522-024-10101-1