Abstract
Over half a century has passed since Alexey Olovnikov's groundbreaking proposal of the end-replication problem in 1971, laying the foundation for our understanding of telomeres and their pivotal role in cellular senescence. This review paper delves into the intricate and multifaceted relationship between cellular senescence, the influence of telomeres in this process, and the far-reaching consequences of telomeres in the context of aging and age-related diseases. Additionally, the paper investigates the various factors that can influence telomere shortening beyond the confines of the end-replication problem and how telomeres can exert their impact on aging, even in the absence of significant shortening. Ultimately, this paper stands as a tribute to the pioneering work of Olovnikov, whose seminal contributions established the solid foundation upon which our ongoing explorations of telomeres and the aging process are based.
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Acknowledgements
This work was funded by NIH grants R01AG068048 (JFP); UH3CA268103 (JFP) and R01AG082708 (JFP, SV) and The Glenn Foundation For Medical Research (JFP). SV would like to acknowledge funding from the Robert and Arlene Kogod Center for Aging Career Development Award.
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ME wrote the first draft of the manuscript, which was then edited and modified by JFP and SV. ME prepared Fig. 1. All authors had input into review or editing the manuscript.
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Eppard, M., Passos, J.F. & Victorelli, S. Telomeres, cellular senescence, and aging: past and future. Biogerontology 25, 329–339 (2024). https://doi.org/10.1007/s10522-023-10085-4
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DOI: https://doi.org/10.1007/s10522-023-10085-4