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Toxin-induced hormesis may restrain aging

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Abstract

Mild environmental stress might have beneficial effects in aging by activating maintenance and repair processes in cells and organs. These beneficial stress effects fit to the concept of hormesis. Prominent stressors acting in a hormetic way are physical exercises, fasting, cold and heat. This review will introduce some toxins, which have been found to induce hormetic responses in animal models of aging research. To highlight the molecular signature of these hormetic effects we will depict signaling pathways affected by low doses of toxins on cellular and organismic level. As prominent examples for signaling pathways involved in both aging processes as well as toxin responses, PI3K/Akt/mTOR- and AMPK-signal transduction will be described in more detail. Due to the striking overlap of signaling pathways mediating toxin induced responses and aging processes we propose considering the ability of low doses of toxins to slow down the rate of aging.

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Author notes

  1. Trim Lajqi and Milan Stojiljkovic have contributed equally to the manuscript.

Authors and Affiliations

  1. Institute of Molecular Cell Biology, Center for Molecular Biomedicine (CMB), Jena University Hospital, Jena, Germany

    Trim Lajqi

  2. Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany

    Milan Stojiljkovic

  3. Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany

    Reinhard Wetzker

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  1. Trim Lajqi
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  2. Milan Stojiljkovic
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  3. Reinhard Wetzker
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Correspondence to Reinhard Wetzker.

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Lajqi, T., Stojiljkovic, M. & Wetzker, R. Toxin-induced hormesis may restrain aging. Biogerontology 20, 571–581 (2019). https://doi.org/10.1007/s10522-019-09806-5

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  • DOI: https://doi.org/10.1007/s10522-019-09806-5

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