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Age-Related Features of the Response of Cancer Stem Cells and T Cells in Experimental Lung Cancer

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The responses of tumor stem cells and various populations of CD4 and CD8 T cells of young and aged C57BL/6 mice were studied in a lung cancer model. Using Lewis lung carcinoma cell line, an orthotopic model of lung cancer was modeled. Cancer stem cells, circulating tumor cells, and various populations of CD4 and CD8 T cells in the blood and lung tissue were studied by cytometry. We revealed age-related differences in the content of various populations of CD4 and CD8 T cells in the blood and lungs of intact young and aged mice. Age-related features of the reaction of various populations of cancer stem cells and CD4 and CD8 T cells in the blood and lungs of animals in the Lewis lung carcinoma were shown.

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Authors and Affiliations

  1. Laboratory of Regenerative Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia

    O. V. Pershina, N. N. Ermakova, A. V. Pakhomova, E. S. Pan, L. A. Sandrikina, M. A. Zhukova, L. V. Kogai & A. M. Dygai

  2. Research Institute of General Pathology and Pathophysiology, Moscow, Russia

    A. M. Dygai & E. G. Skurikhin

Authors
  1. O. V. Pershina
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  2. N. N. Ermakova
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  3. A. V. Pakhomova
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  4. E. S. Pan
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  5. L. A. Sandrikina
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  6. M. A. Zhukova
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  7. L. V. Kogai
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  8. A. M. Dygai
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  9. E. G. Skurikhin
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Corresponding author

Correspondence to O. V. Pershina.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 176, No. 10, pp. 488-493, October, 2023

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Pershina, O.V., Ermakova, N.N., Pakhomova, A.V. et al. Age-Related Features of the Response of Cancer Stem Cells and T Cells in Experimental Lung Cancer. Bull Exp Biol Med 176, 486–490 (2024). https://doi.org/10.1007/s10517-024-06052-9

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  • DOI: https://doi.org/10.1007/s10517-024-06052-9

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