We studied some features of blood and lymph microcirculation in the brain, heart, and liver of female rats with developed alcoholic cardiomyopathy. In female rats after 24-week forced consumption of 10% ethanol solution, the size and inotropic function of the heart were measured by echocardiography. Microcirculation in the brain, myocardium, and liver was assessed by laser Doppler flowmetry using LAKK-OP2 and LAZMA-D computerized laser analyzers. Using spectral wavelet analysis, we determined the absolute and normalized to total perfusion amplitudes of microcirculation oscillations reflecting various regulatory mechanisms. Intact animals served as controls. In rats of the experimental group, alcoholic cardiomyopathy completely developed. Under these conditions, the index of microcirculation in the brain, myocardium, and liver significantly decreased. At the same time, there was a redistribution in the brain between shunting and nutritive blood flow in favor of the latter. In the myocardium and liver, this ratio did not change.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bokhan NA, Mandel’ AI, Maksimenko NN, Mikhaleva LD. Lethal outcomes in alcoholism. Narkologiya. 2007;6(12):37-40. Russian.
Tibiriçá E, Lorenzo A, Oliveira GMM. Microcirculation and Cardiovascular Diseases. Arq. Bras. Cardiol. 2018;111(2):120-121. https://doi.org/10.5935/abc.20180149
Cuculi F, De Caterina AR, Kharbanda RK, Banning AP. Optimal reperfusion in ST-elevation myocardial infarction — the role of the coronary microcirculation. Swiss Med. Wkly. 2011;141:w13313. https://doi.org/10.4414/smw.2011.13313
Holubarsch CJ. Endothelial dysfunction: impact on epicardial coronary arteries and microcirculation. Semin. Thromb. Hemost. 2000;26(5):547-551. https://doi.org/10.1055/s-2000-13211
Jalali Z, Khademalhosseini M, Soltani N, Esmaeili Nadimi A. Smoking, alcohol and opioids effect on coronary microcirculation: an update overview. BMC Cardiovasc. Disord. 2021;21(1):185. https://doi.org/10.1186/s12872-021-01990-y
Doggett TM, Breslin JW. Acute alcohol intoxication-induced microvascular leakage. Alcohol. Clin. Exp. Res. 2014;38(9):2414-2426. https://doi.org/10.1111/acer.12525
Kryzhanovskii SA, Kolik LG, Tsorin IB, Stolyaruk VN, Vititnova MB, Ionova EO, Sorokina AV, Durnev AD. Alcoholic cardiomyopathy: translation model. Bull. Exp. Biol. Med. 2017;163(5):627-631. https://doi.org/10.1007/s10517-017-3865-0
Kozhevnikova LM, Tsorin IB, Ionova EO, Barchukov VV, Nikiforova TD, Shigabudinova LK, Stolyaruk VN, Vititnova MB, Kolik LG, Durnev AD, Kryzhanovskii SA. Sex-related changes in the cardiovascular system in alcoholic cardiomyopathy (an experimental study). Patol. Fiziol. Eksper. Ter. 2019;63(4):23-31. Russian. https://doi.org/10.25557/0031-2991.2019.04.23-31
Fernández-Solà J, Nicolás-Arfelis JM. Gender differences in alcoholic cardiomyopathy. J. Gend. Specif. Med. 2002;5(1):41-47.
Pankuweit S. Alcohol consumption in women and the elderly: When does it induce heart failure? Herz. 2016;41(6):494-497. https://doi.org/10.1007/s00059-016-4462-0
Krupatkin AI, Sidorov VV. Functional Diagnostics of Microcirculatory-Tissue Systems: Vibrations, Information, Nonlinearity. Moscow, 2013. Russian.
Sidorov VV, Rybakov YuL, Gukasov VM. Diagnostic approach for estimation of the state of microcirculator-tissue system using laser technologies and temperature functional sample. Inovatika Ekspertiza. 2018;(Issue 1):135-142.
Sun BL, Wang LH, Yang T, Sun JY, Mao LL, Yang MF, Yuan H, Colvin RA, Yang XY. Lymphatic drainage system of the brain: A novel target for intervention of neurological diseases. Prog. Neurobiol. 2018;163-164;118-143. https://doi.org/10.1016/j.pneurobio.2017.08.007
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 175, No. 4, pp. 436-440, April, 2023
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Tsorin, I.B., Efimova, A.O., Vititnova, M.V. et al. Changes in Microcirculation in the Brain, Heart, and Liver in Female Rats with Translational Model of Alcoholic Cardiomyopathy. Bull Exp Biol Med 175, 442–445 (2023). https://doi.org/10.1007/s10517-023-05885-0
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-023-05885-0