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Long-Term Effect of Moderate Hypoxia and Chronic Administration of Fluoxetine during the Neonatal Period on Cognitive and Stress-Hormonal Functions in Adult Male Rats

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We studied the effect of moderate neonatal normobaric hypoxia on the indicators of spatial learning, memory, and reactivity of the hypothalamic—pituitary—adrenocortical system in adult male Wistar rats. The pharmacological effect of chronic injections of the serotonin reuptake inhibitor fluoxetine during the neonatal period on the studied behavioral and the physiological indices was evaluated. Hypoxia impaired spatial training, increased the short-term memory performance, but did not change long-term memory and stress indicator in response to its testing. The use of fluoxetine normalized learning, but did not change memory indicators and the stress-induced level of corticosterone in blood plasma in the hypoxic rats and control animals. New results indicate a protective effect of fluoxetine in the neonatal period under conditions of moderate normobaric hypoxia.

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References

  1. Millar LJ, Shi L, Hoerder-Suabedissen A, Molnár Z. Neonatal Hypoxia Ischaemia: Mechanisms, Models, and Therapeutic Challenges. Front. Cell. Neurosci. 2017. Vol. 11. P. 78. doi: https://doi.org/10.3389/fncel.2017.00078

  2. Carneiro IBC, Toscano AE, da Cunha MSB, Lacerda DC, Pontes PB, de Castro RM, de Jesus Deiró TCB, Medeiros JMB. Serotonergic mechanisms associated with experimental models of hypoxia: A systematic review. Int. J. Dev. Neurosci. 2022;82(8):668-680. doi: https://doi.org/10.1002/jdn.10226

    Article  CAS  PubMed  Google Scholar 

  3. Azmitia EC. Modern views on an ancient chemical: serotonin effects on cell proliferation, maturation, and apoptosis. Brain Res. Bull. 2001;56(5):413-424. doi: https://doi.org/10.1016/s0361-9230(01)00614-1

    Article  CAS  PubMed  Google Scholar 

  4. Elvander-Tottie E, Eriksson TM, Sandin J, Ogren SO. 5-HT(1A) and NMDA receptors interact in the rat medial septum and modulate hippocampal-dependent spatial learning. Hippocampus. 2009;19(12):1187-1198. doi: https://doi.org/10.1002/hipo.20596

    Article  CAS  PubMed  Google Scholar 

  5. Vorhees CV, Williams MT. Assessing spatial learning and memory in rodents. ILAR J. 2014;55(2):310-332. doi: https://doi.org/10.1093/ilar/ilu013

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Bombardi C, Grandis A, Pivac N, Sagud M, Lucas G, Chagraoui A, Lemaire-Mayo V, De Deurwaerdère P, Di Giovanni G. Serotonin modulation of hippocampal functions: From anatomy to neurotherapeutics. Prog. Brain Res. 2021;261:83-158. doi: https://doi.org/10.1016/bs.pbr.2021.01.031

    Article  PubMed  Google Scholar 

  7. Concepcion KR, Zhang L. Corticosteroids and perinatal hypoxic-ischemic brain injury. Drug Discov. Today. 2018;23(10):1718-1732. doi: https://doi.org/10.1016/j.drudis.2018.05.019

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Chang YC, Tzeng SF, Yu L, Huang AM, Lee HT, Huang CC, Ho CJ. Early-life fluoxetine exposure reduced functional deficits after hypoxic-ischemia brain injury in rat pups. Neurobiol. Dis. 2006;24(1):101-113. doi: https://doi.org/10.1016/j.nbd.2006.06.001

    Article  CAS  PubMed  Google Scholar 

  9. El Sayed NS, Salah El Dine R, Budzyńska B, Boguszewska-Czubara A, Kotlińska J. Editorial: Central nervous system acting drugs-molecular mechanisms of neuroprotection and neurodegeneration. Front. Neurosci. 2022;16:1060515. doi: https://doi.org/10.3389/fnins.2022.1060515

  10. Tate K, Kirk B, Tseng A, Ulffers A, Litwa K. Effects of the Selective Serotonin Reuptake Inhibitor Fluoxetine on Developing Neural Circuits in a Model of the Human Fetal Cortex. Int. J. Mol. Sci. 2021;22(19):10457. doi: https://doi.org/10.3390/ijms221910457

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Cohen SJ, Stackman RW Jr. Assessing rodent hippocampal involvement in the novel object recognition task. A review. Behav. Brain Res. 2015;285:105-117. doi: https://doi.org/10.1016/j.bbr.2014.08.002

    Article  PubMed  Google Scholar 

  12. Butkevich IP, Mikhailenko VA. Effect of Fluoxetine in Prenatal Period on Nociceptive System Reactivity and Psychoemotional Behavior in Young Female Rats. Bull. Exp. Biol. Med. 2018;165(2):209-212. doi: https://doi.org/10.1007/s10517-018-4131-9

    Article  CAS  PubMed  Google Scholar 

  13. France G, Volianskis R, Ingram R, Bannister N, Rothärmel R, Irvine MW, Fang G, Burnell ES, Sapkota K, Costa BM, Chopra DA, Dravid SM, Michael-Titus AT, Monaghan DT, Georgiou J, Bortolotto ZA, Jane DE, Collingridge GL, Volianskis A. Differential regulation of STP, LTP and LTD by structurally diverse NMDA receptor subunit-specific positive allosteric modulators. Neuropharmacology. 2022;202:108840. doi: https://doi.org/10.1016/j.neuropharm.2021.108840

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Authors and Affiliations

  1. Laboratory of Ontogenesis of Nervous System, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    V. A. Mikhailenko & I. P. Butkevich

  2. Laboratory of Information Technologies and Mathematical Modeling, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    E. A. Vershinina

Authors
  1. V. A. Mikhailenko
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  2. I. P. Butkevich
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  3. E. A. Vershinina
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Correspondence to V. A. Mikhailenko.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 175, No. 2, pp. 156-160, February, 2023

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Mikhailenko, V.A., Butkevich, I.P. & Vershinina, E.A. Long-Term Effect of Moderate Hypoxia and Chronic Administration of Fluoxetine during the Neonatal Period on Cognitive and Stress-Hormonal Functions in Adult Male Rats. Bull Exp Biol Med 175, 196–200 (2023). https://doi.org/10.1007/s10517-023-05853-8

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