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Role of PI3K, ERK1/2, and JAK2 Kinases in the Cardioprotective Effect of Deltorphin II during Cardiac Reperfusion

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The signaling mechanism of the cardioprotective effect of deltorphin II was studied in models of coronary occlusion (45 min) and reperfusion (120 min) in male Wistar rats. We used the selective δ2-opioid receptor agonist deltorphin II (0.12 mg/kg), which was administered intravenously 5 min before reperfusion, the PI3K inhibitor wortmannin (0.025 mg/kg), the ERK1/2 blocker PD-098059 (0.5 mg/kg), the inhibitor JAK2 AG490 (3 mg/kg). All kinase blockers were administered 10 min before reperfusion. The infarct-limiting effect of deltorphin II is associated with the activation of PI3K and ERK1/2 and does not depend on JAK2.

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Authors and Affiliations

  1. Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia

    A. V. Mukhomedzyanov, S. V. Popov & L. N. Maslov

  2. Instituto de Fisiología, FCM — UNCuyo, IMBECU — CONICET-UNCuyo, Mendoza, Argentina

    E. R. Diez

  3. Branch of M. M. Shemyakin and Yu. A. Ov-chinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino, Moscow region, Russia

    V. N. Azev

Authors
  1. A. V. Mukhomedzyanov
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  2. S. V. Popov
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  3. L. N. Maslov
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  4. E. R. Diez
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  5. V. N. Azev
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Corresponding author

Correspondence to A. V. Mukhomedzyanov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 175, No. 1, pp. 21-24, January, 2023

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Mukhomedzyanov, A.V., Popov, S.V., Maslov, L.N. et al. Role of PI3K, ERK1/2, and JAK2 Kinases in the Cardioprotective Effect of Deltorphin II during Cardiac Reperfusion. Bull Exp Biol Med 175, 17–19 (2023). https://doi.org/10.1007/s10517-023-05801-6

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  • DOI: https://doi.org/10.1007/s10517-023-05801-6

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