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Role of Na+,K+-ATPase in Bone Remodeling

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The effects of cardiotonic steroids (ouabain and digoxin) on the bone formation were studied using the organotypic tissue culture in combination with confocal microscopy. The expression of α1- and α3-isoforms of Na+,K+-ATPase was detected in cells of the bone tissue of 12-day-old chicken embryos. Ouabain in a concentrations 10-10 M (comparable with its endogenous concentration) can modulate transducer function of Na+,K+-ATPase and control the growth and proliferation bone tissue cells. Unlike ouabain, digoxin is not involved in the regulation of bone tissue growth in a 12-day-old chicken embryo.

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Authors and Affiliations

  1. I. P. Pavlov First St. Petersburg State Medical University, Ministry of Health of the Russian Federation, St. Petersburg, Russia

    N. A. Pasatetskaya, S. I. Klimshin & E. V. Lopatina

  2. I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    E. V. Lopatina

Authors
  1. N. A. Pasatetskaya
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  2. S. I. Klimshin
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  3. E. V. Lopatina
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Correspondence to N. A. Pasatetskaya.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 174, No. 11, pp. 642-645, November, 2022

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Pasatetskaya, N.A., Klimshin, S.I. & Lopatina, E.V. Role of Na+,K+-ATPase in Bone Remodeling. Bull Exp Biol Med 174, 678–680 (2023). https://doi.org/10.1007/s10517-023-05768-4

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  • DOI: https://doi.org/10.1007/s10517-023-05768-4

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