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Effect of Glycodelin on the Cytokine Profile of Rats during Allogeneic Bone Marrow Cell Transplantation

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The protein glycodelin (PP14, PAEP) is associated with pregnancy and exhibits pronounced immunotropic properties. We studied the effect of glycodelin on the cytokine profile of blood serum during transplantation a suspension of allogeneic red bone marrow cells to Wistar rats. Recombinant glycodelin was administered to the animals 4 times (14 μg each time). Against the background of bone marrow cell transplantation, the levels of proinflammatory (IL-1α, IL-1β, and IL-18) and regulatory (IL-7, IL-12) cytokines and CSF (M-CSF) increased in blood serum, which indicates a systemic inflammatory response to the allograft. Glycodelin administration against the background of bone marrow cell allotransplantation led to a significant decrease in the proinflammatory cytokine IL-17A on day 21 of the experiment; the concentrations of the other cytokines remained unchanged. In general, glycodelin can suppress the level of IL-17A, a marker of graft rejection, which opens perspectives for its further investigation as a potential drug.

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Authors and Affiliations

  1. Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences — Branch of Perm State Research Center, Ural Division of the Russian Academy of Sciences, Perm, Russia

    M. S. Bochkova, V. P. Timganova, K. Yu Shardina, S. V. Uzhviyuk & S. A. Zamorina

  2. Perm State National Research University, Perm, Russia

    M. S. Bochkova & S. A. Zamorina

  3. E. A. Vagner Perm State Medical University, Ministry of Health of the Russian Federation, Perm, Russia

    N. P. Loginova & Ya. N. Troinich

Authors
  1. M. S. Bochkova
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  2. V. P. Timganova
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  3. K. Yu Shardina
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  4. S. V. Uzhviyuk
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  5. N. P. Loginova
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  6. Ya. N. Troinich
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  7. S. A. Zamorina
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Correspondence to M. S. Bochkova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 173, No. 5, pp. 606-610, May, 2022

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Bochkova, M.S., Timganova, V.P., Shardina, K.Y. et al. Effect of Glycodelin on the Cytokine Profile of Rats during Allogeneic Bone Marrow Cell Transplantation. Bull Exp Biol Med 173, 636–640 (2022). https://doi.org/10.1007/s10517-022-05603-2

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  • DOI: https://doi.org/10.1007/s10517-022-05603-2

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