Comparison of activity of antibiotics against Staphylococcus aureus strains in their plankton form and in biofilms of varying maturity showed that the concentrations of antibiotics causing death of 90% S. aureus strains (MIC90) in their plankton form was 0.07-2.80 μg/ml and significantly (p<0.05) differed from MIC90 concentrations (3-245 μg/ml) for the strains in 24 and 48 h biofilms. MIC90 value was affected by the degree of biofilm maturity: microbial resistance in 48-h biofilms for all analyzed antibiotics was significantly (p<0.05) higher than in 24-h biofilms.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 172, No. 7, pp. 56-59, July, 2021
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Babushkina, I.V., Mamonova, I.A., Ulyanov, V.Y. et al. Antibiotic Susceptibility of Staphylococcus aureus Plankton and Biofilm Forms Isolated in Implant-Associated Infection. Bull Exp Biol Med 172, 46–48 (2021). https://doi.org/10.1007/s10517-021-05328-8
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DOI: https://doi.org/10.1007/s10517-021-05328-8