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Effect of Cholecystokinin-8 (CCK-8) on Blood Pressure and Blood Content of Calcitonin-Gene-Related Peptide (CGRP) in Rats with Hypertension Caused by Fructose or Inhibition of Nitric Oxide Synthesis

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We studied the effect of CCK-8 on BP and blood content of CGRP in rats with hypertension caused by fructose or inhibition of NO synthase with L-NAME. The decrease in the CGRP content was found during the development of fructose-induced hypertension, but not L-NAME-caused hypertension. Administration of CCK-8 to fructose-fed animals reduced BP and increased the content of CGRP. In rats with hypertension caused by NO deficit, CCK-8 lowered BP, but did not affect the content of CGRP. These findings suggest that CGRP mediates the hypotensive effect of CCK-8 in fructose-induced hypertension, but not in NO-deficient hypertension.

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Authors and Affiliations

  1. Research Institute of Neurosciences and Medicine, Novosibirsk, Russia

    Z. S. Tolochko & V. K. Spiridonov

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  1. Z. S. Tolochko
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  2. V. K. Spiridonov
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Correspondence to Z. S. Tolochko.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 171, No. 5, pp. 608-612, May, 2021

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Tolochko, Z.S., Spiridonov, V.K. Effect of Cholecystokinin-8 (CCK-8) on Blood Pressure and Blood Content of Calcitonin-Gene-Related Peptide (CGRP) in Rats with Hypertension Caused by Fructose or Inhibition of Nitric Oxide Synthesis. Bull Exp Biol Med 171, 633–637 (2021). https://doi.org/10.1007/s10517-021-05284-3

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  • DOI: https://doi.org/10.1007/s10517-021-05284-3

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