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Depolarization of the Atrial Subepicardium in Rats with Experimentally Induced Pulmonary Hypertension

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Bulletin of Experimental Biology and Medicine Aims and scope

Using an experimental model of pulmonary hypertension in rats (monocrotaline in a dose of 60 mg/kg), we revealed an additional focus of early excitation in the zone where the pulmonary veins enter the left atrium, in addition to the main focus in the sinoatrial node. Pulmonary hypertension leads to the formation of regions of early activation in the right and left atria and a significant change in the sequence of atrial depolarization. Propagation of independent excitation waves in the right and left atria increases heterogeneity of depolarization and leads to the formation of atrial arrhythmias.

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Authors and Affiliations

  1. Department of Comparative Cardiology, Federal Research Centre Komi Research Centre, Ural Division of the Russian Academy of Sciences, Syktyvkar, Russia

    S. L. Smirnova

  2. V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia

    I. M. Roshchevskaya

Authors
  1. S. L. Smirnova
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  2. I. M. Roshchevskaya
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Correspondence to S. L. Smirnova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 170, No. 12, pp. 725-728, December, 2020

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Smirnova, S.L., Roshchevskaya, I.M. Depolarization of the Atrial Subepicardium in Rats with Experimentally Induced Pulmonary Hypertension. Bull Exp Biol Med 170, 741–743 (2021). https://doi.org/10.1007/s10517-021-05145-z

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  • DOI: https://doi.org/10.1007/s10517-021-05145-z

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