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Functional State of Mesenchymal Stem Cells upon Exposure to Bioactive Coatings on Titanium Alloys

  • Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Bioactive coatings on implants affect osteogenic differentiation of mesenchymal stem cells (MSC). We studied the morphofunctional state of bone marrow MSC cultured on the surface of calcium phosphate coatings on titanium formed by plasma electrolytic oxidation (PEO). The biocompatible properties of the coatings manifested in the absence of the cytotoxic effect on cells. High expression of receptors (CD90, CD29, and CD106), enhanced synthesis of osteocalcin and osteopontin, and changes in surface architectonics of MSC adherent to the samples confirmed osteoinductive properties of the calcium phosphate PEO coating.

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Authors and Affiliations

  1. Central Research Laboratory, Pacific State Medical University, the Ministry of Health of the Russian Federation, Vladivostok, Russia

    N. G. Plekhova & D. V. Shevchuk

  2. G. P. Somov Research Institute Epidemiology and Microbiology, Vladivostok, Russia

    I. N. Lyapun & E. I. Drobot

  3. Institute of Chemistry, Far-Eastern Division of the Russian Academy of Sciences, Vladivostok, Russia

    S. L. Sinebryukhov, D. V. Mashtalyar & S. V. Gnedenkov

Authors
  1. N. G. Plekhova
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  2. I. N. Lyapun
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  3. E. I. Drobot
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  4. D. V. Shevchuk
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  5. S. L. Sinebryukhov
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  6. D. V. Mashtalyar
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  7. S. V. Gnedenkov
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Correspondence to N. G. Plekhova.

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Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 1, pp. 30-40, January, 2020

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Plekhova, N.G., Lyapun, I.N., Drobot, E.I. et al. Functional State of Mesenchymal Stem Cells upon Exposure to Bioactive Coatings on Titanium Alloys. Bull Exp Biol Med 169, 147–156 (2020). https://doi.org/10.1007/s10517-020-04841-6

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  • DOI: https://doi.org/10.1007/s10517-020-04841-6

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