Expression of neuronal NO synthase in the sympathetic cranial cervical ganglion and stellate ganglion in rats during postnatal ontogeny was studied by immunohistochemistry and Western blotting. In the sympathetic ganglia, neuronal NO synthase-immunoreactive neurons were absent in all rats. In the stellate and cranial cervical ganglia, the expression of neuronal NO synthase and the density of immunoreactive fibers increased in early postnatal ontogeny from the moment of birth to the age of 30 days and then decreased. Thus, we observed heterochroneous expression of neuronal NOS in the preganglionic somata in the spinal cord and in the preganglionic fibers in the sympathetic ganglia during ontogeny.
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Kolos YeA, Korzhevskiy DE. The distribution of cholinergic and nitroxidergic neurons in the spinal cord of newborn and adult rats. Morfologiya. 2015;147(2):32-37. Russian.
Masliukov PM. Connections of the cat stellate ganglion with target organs during postnatal ontogeny. Ross. Fiziol. Zh. 2000;86(6):703-710. Russian.
Moiseyev KYu, Masliukov PM. Age-related changes of nocontaining sympathetic neurons in rat spinal cord. Morfologiya. 2018;153(1):23-27. Russian.
Nozdrachev AD, Masliukov PM. Age Development of Autonomic Ganglionic Neurons. St. Petersburg, 2014. Russian.
Sitdikova GF, Zefirov AL. Gaseous messengers in the nervous system. Ross. Fiziol. Zh. 2006;92(7):872-882. Russian.
Dun NJ, Dun SL, Forstermann U, Tseng LF. Nitric oxide synthase immunoreactivity in rat spinal cord. Neurosci. Lett. 1992;147(2):217-220.
Emanuilov AI, Korzina MB, Archakova LI, Novakovskaya SA, Nozdrachev AD, Masliukov PM. Development of the NADPHdiaphorase-positive neurons in the sympathetic ganglia. Ann. Anat. 2008;190(6):516-524.
Garthwaite J. NO as a multimodal transmitter in the brain: discovery and current status. Br. J. Pharmacol. 2019;176(2):197-211.
Masliukov PM, Fateev MM, Nozdrachev AD. Age-dependent changes of electrophysiologic characteristics of the stellate ganglion conducting pathways in kittens. Auton. Neurosci. 2000;83(1-2):12-18.
Moiseev KY, Romanova IV, Masliukov AP, Masliukov PM. Development of nNOS-positive preganglionic sympathetic neurons in the rat thoracic spinal cord. Cell. Tissue Res. 2019;375(2):345-357.
Phan Duy A, Pham H, Pansiot J, Gressens P, Charriaut-Marlangue C, Baud O. Nitric Oxide Pathway and Proliferation of Neural Progenitors in the Neonatal Rat. Dev. Neurosci. 2015;37(4-5):417-427.
Philippu A. Nitric Oxide: A Universal Modulator of Brain Function. Curr. Med. Chem. 2016;23(24):2643-2652.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 168, No. 7, pp. 88-90, July, 2019
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Moiseev, K.Y., Yukhmankova, A.V. & Masliukov, P.M. Changes of the Expression of Neuronal NO-Synthase in Rat Sympathetic Ganglia during Ontogeny. Bull Exp Biol Med 168, 76–78 (2019). https://doi.org/10.1007/s10517-019-04651-5
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DOI: https://doi.org/10.1007/s10517-019-04651-5