The effects of environmental factors (flavors, different ethanol concentration, alcoholic deprivation, and food reinforcement) on the formation of alcohol motivation was studied in rhesus macaques (Macaca mulatta, n=6). Motivation for alcohol intake was induced in two stages: initiation (sessions 1-160) and formation of motivation (sessions 161-516). Monkeys preferred multifruit flavor and 4% ethanol solution, while ethanol deprivation did not stimulate alcohol consumption. The pronounced individual differences in the pattern of alcohol motivation were revealed: the intake of 4% ethanol solution ranged from 0.21±0.03 to 0.43±0.06 g/kg without food reinforcement and increased from 0.78±0.03 to 1.22±0.09 g/kg with food reinforcement. The results suggest that the proposed method is valid and can be used as an experimental model of alcohol dependence in non-human primates.
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References
Kozhechkin SN, Mednikova YS, Kolik LG. Effects of naltrexone on firing activity of rat cortex neurons and its interactions with ethanol. Bull. Exp. Biol. Med. 2013;155(5):639-642.
Kolik LG, Nadorova AV, Kozlovskaya MM. Efficacy of peptide anxiolytic selank during modeling of withdrawal syndrome in rats with stable alcohol motivation. Bull. Exp. Biol. Med. 2014;157(1):52-55.
Allen DC, Gonzales SW, Grant KA. Effect of repeated abstinence on chronic ethanol self-administration in the rhesus monkey. Psychopharmacology (Berl). 2018;235(1):109-120.
Baker EJ, Walter NA, Salo A, Rivas Perea P, Moore S, Gonzales S, Grant KA. Identifying Future Drinkers: Behavioral Analysis of Monkeys Initiating Drinking to Intoxication is Predictive of Future Drinking Classification. Alcohol. Clin. Exp. Res. 2017;41(3):626-636.
Carnicella S, Ron D, Barak S. Intermittent ethanol access schedule in rats as a preclinical model of alcohol abuse. Alcohol. 2014;48(3):243-252.
Grant KA, Bennett AJ. Advances in nonhuman primate alcohol abuse and alcoholism research. Pharmacol. Ther. 2003;100(3):235-255.
Grant KA, Leng X, Green HL, Szeliga KT, Rogers LS, Gonzales SW. Drinking typography established by scheduled induction predicts chronic heavy drinking in a monkey model of ethanol self-administration. Alcohol. Clin. Exp. Res. 2008;32(10):1824-1838.
Katner SN, Flynn CT, Von Huben SN, Kirsten AJ, Davis SA, Lay CC, Cole M, Roberts AJ, Fox HS, Taffe MA. Controlled and behaviorally relevant levels of oral ethanol intake in rhesus macaques using a flavorant-fade procedure. Alcohol. Clin. Exp. Res. 2004;28(6):873-883
Vengeliene V, Bilbao A, Spanagel R. The alcohol deprivation effect model for studying relapse behavior: a comparison between rats and mice. Alcohol. 2014;48(3):313-320.
Wills TA, Knapp DJ, Overstreet DH, Breese GR. Differential dietary ethanol intake and blood ethanol levels in adolescent and adult rats: effects on anxiety-like behavior and seizure thresholds. Alcohol. Clin. Exp. Res. 2008;32(8):1350-1360.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 167, No. 4, pp. 505-509, April, 2019
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Shmaliy, A.V., Pavlova, L.E., Chuguev, Y.P. et al. Formation of Alcohol Motivation in Monkeys (Macaca mulatta) Kept in Isolation. Bull Exp Biol Med 167, 516–520 (2019). https://doi.org/10.1007/s10517-019-04563-4
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DOI: https://doi.org/10.1007/s10517-019-04563-4