The effects of endocrine disrupters of transcriptional control of morphogenesis are poorly studied. Changes in the expression of transcriptional factor PRH and proliferation of adrenal cortical cells were analyzed in pubertal and postpubertal rats exposed prenatally and postnatally to low doses of endocrine disrupter DDT. In rats exposed to DDT, the expression of PRH and proliferation of adrenal cortical cells differed from those in control rats. Association between these parameters was weakened in the zona glomerulosa and zona reticularis and was absent in the zona fasciculata. These findings suggest that exposure to DDT in pre- and postnatal periods impairs the regulation of proliferative processes by transcriptional factor PRH in all zones of rat adrenal cortex, which can be a mechanism of the disruptive action of DDT.
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References
Technical Regulation of the Customs Union 021/2011 “On food safety”. St. Petersburg, 2015. Russian.
Tsomartova DA, Yaglova NV, Yaglov VV. Changes in Canonical β-Catenin/Wnt Signaling Activation in the Adrenal Cortex of Rats Exposed to Endocrine Disruptor Dichlorodiphenyltrichloroethane (DDT) during Prenatal and Postnatal Ontogeny. Bull. Exp. Biol. Med. 2018;164(4):493-496.
Yaglova NV, Obernikhin SS, Tsomartova DA, Nazimova SV, Yaglov VV. Expression of Transcription Factor PRH/Hhex in Adrenal Chromaffin Cells in the Postnatal Development and Its Role in the Regulation of Proliferative Processes. Bull. Exp. Biol. Med. 2018;165(4):508-511.
Cong R, Jiang X, Wilson CM, Hunter MP, Vasavada H, Bogue CW. Hhex is a direct repressor of endothelial cell-specific molecule 1 (ESM-1). Biochem. Biophys. Res. Commun. 2006;346(2):535-545.
Crompton MR, Bartlett TJ, MacGregor AD, Manfioletti G, Buratti E, Giancotti V, Goodwin GH. Identification of a novel vertebrate homeobox gene expressed in haematopoietic cells. Nucleic Acids Res. 1992;20(21):5661-5567.
Kershaw RM, Roberts D, Wragg J, Shaaban AM, Humphreys E, Halsall J, Price L, Bicknell R, Gaston K, Jayaraman PS. Proline-Rich Homeodomain protein (PRH/HHEX) is a suppressor of breast tumour growth. Oncogenesis. 2017;6(6. e346. doi: https://doi.org/10.1038/oncsis.2017.42.
Kershaw RM, Siddiqui YH, Roberts D, Jayaraman PS, Gaston K. PRH/HHex inhibits the migration of breast and prostate epithelial cells through direct transcriptional regulation of Endoglin. Oncogene. 2014;33(49):5592-5600.
Noy P, Williams H, Sawasdichai A, Gaston K, Jayaraman PS. PRH/Hhex controls cell survival through coordinate transcriptional regulation of vascular endothelial growth factor signaling. Mol. Cell. Biol. 2010;30(9):2120-2134. doi: https://doi.org/10.1128/MCB.01511-09.
Pignatelli D, Xiao F, Gouveia AM, Ferreira JG, Vinson GP. Adrenarche in the rat. J. Endocrinol. 2006;191(1):301-308.
Topisirovic I, Culjkovic B, Cohen N, Perez JM, Skrabanek L, Borden KL. The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth. EMBO J. 2003;22(3):689-703.
Tyczewska M, Rucinski M, Ziolkowska A, Szyszka M, Trejter M, Hochol-Molenda A, Nowak KW, Malendowicz LK. Enucleation-induced rat adrenal gland regeneration: expression profile of selected genes involved in control of adrenocortical cell proliferation. Int. J. Endocrinol. 2014;2014. 130359. doi: https://doi.org/10.1155/2014/130359.
Yamazaki H, Takano R, Shimizu M, Murayama N, Kitajima M, Shono M. Human blood concentrations of dichlorodiphenyltrichloroethane (DDT) extrapolated from metabolism in rats and humans and physiologically based pharmacokinetic modeling. J. Health Sci. 2010;56(5):566-575.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 167, No. 3, pp. 381-385, March, 2019
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Yaglova, N.V., Tsomartova, D.A., Obernikhin, S.S. et al. Regulation of Proliferative Processes in Rat Adrenal Cortex by Transcriptional Factor PRH under Conditions of Developmental Exposure to Endocrine Disruptor DDT. Bull Exp Biol Med 167, 404–407 (2019). https://doi.org/10.1007/s10517-019-04537-6
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DOI: https://doi.org/10.1007/s10517-019-04537-6