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Effect of Selank on Morphological Parameters of Rat Liver in Chronic Foot-Shock Stress

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We studied the effects of Selank on morphological parameters of the liver in Wistar male rats subjected to chronic foot-shock stress. Selank was injected intraperitoneally in doses of 100, 300 and 1000 μg/kg 15 min before each stress session. Morphological and morphometrical analysis showed that chronic foot-shock stress induced hydropic degeneration of hepatocytes, an increase of the nucleus/cytoplasm ratio due to an increase in the area of nuclei and reduction of the cytoplasm area, the appearance of focal necroses, and lymphohistiocyte infiltration. Injection of Selank in all doses reduced the intensity of stress-induced degenerative changes. Administration of Selank in doses of 300 and 1000 μg/kg restored the nucleus/cytoplasm ratio in hepatocytes. The maximum stress-limiting effect was attained after administration of 300 μg/kg Selank.

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Authors and Affiliations

  1. Department of Histology, Cytology, and Embryology, Moscow, Russia

    E. V. Fomenko & A. V. Ivanov

  2. Department of Pathophysiology, Moscow, Russia

    I. I. Bobyntsev & A. E. Belykh

  3. Research Institute of General Pathology, Kursk State Medical University, Kursk, Russia

    I. I. Bobyntsev, A. V. Ivanov & A. E. Belykh

  4. Department of Chemistry of Physiologically Active Substances, Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia

    L. A. Andreeva & N. F. Myasoedov

Authors
  1. E. V. Fomenko
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  2. I. I. Bobyntsev
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  3. A. V. Ivanov
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  4. A. E. Belykh
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  5. L. A. Andreeva
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  6. N. F. Myasoedov
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Corresponding author

Correspondence to I. I. Bobyntsev.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 167, No. 2, pp. 257-260, February, 2019

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Fomenko, E.V., Bobyntsev, I.I., Ivanov, A.V. et al. Effect of Selank on Morphological Parameters of Rat Liver in Chronic Foot-Shock Stress. Bull Exp Biol Med 167, 293–296 (2019). https://doi.org/10.1007/s10517-019-04512-1

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  • DOI: https://doi.org/10.1007/s10517-019-04512-1

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