We studied the effect of low and high-dose rate photon radiation on activation of cell death by apoptosis and necrosis in malignant cell lines of lymphocytic origin Raji and Jurkat (human B and T-cell lymphomas) and normal human lymphocytes from healthy volunteers. It was shown that photon radiation with ultra-high dose rate induced significantly higher levels of “early” apoptosis and lower levels of necrosis compared to γ-radiation with dose rate used for radiation therapy.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 166, No. 12, pp. 753-756, December, 2018
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Bozhenko, V.K., Ivanov, A.V., Kulinich, T.M. et al. Comparison of Biological Effects of γ-Radiation of Low and Ultra-High Dose Rate on Lymphocytes and Cultured Human Malignant Lymphoma Cells. Bull Exp Biol Med 166, 785–787 (2019). https://doi.org/10.1007/s10517-019-04440-0
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DOI: https://doi.org/10.1007/s10517-019-04440-0