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Mitochondria-Associated Matrix Metalloproteinases 2 and 9 in Acute Renal Pathologies

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Activities of MMP-2 and MMP-9 in the cytoplasm and mitochondria of kidney cells were evaluated on the models of acute renal pathologies: pyelonephritis, rhabdomyolysis, and ischemia/reperfusion of the kidney. In acute pyelonephritis, a significant increase in the level of MMP-2 and MMP-9 in kidney cells and the appearance of mitochondrial MMP-2 isoform with a lower molecular weight, but still exhibiting proteolytic activity were observed. A direct correlation between the level of MMP-2 and MMP-9 in the kidney and the severity of inflammation in pyelonephritis was revealed. Obviously, the appearance of active protease in the mitochondria of the kidney cells could have an impact on their functioning and, generally, on the fate of renal cells in this pathology.

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Authors and Affiliations

  1. A. N. Belozersky Research Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University, Moscow, Russia

    I. B. Pevzner, L. D. Zorova, E. Yu. Plotnikov & D. B. Zorov

  2. V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Moscow, Russia

    I. B. Pevzner, L. D. Zorova, E. Yu. Plotnikov & D. B. Zorov

  3. Faculty and Bioengineering and Bioinformatics, M. V. Lomonosov Moscow State University, Moskva, Russia

    F. A. Galkin

  4. I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation, Moscow, Russia

    E. Yu. Plotnikov

Authors
  1. I. B. Pevzner
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  2. L. D. Zorova
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  3. F. A. Galkin
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  4. E. Yu. Plotnikov
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  5. D. B. Zorov
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Corresponding author

Correspondence to E. Yu. Plotnikov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 166, No. 9, pp. 304-309, September, 2018

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Pevzner, I.B., Zorova, L.D., Galkin, F.A. et al. Mitochondria-Associated Matrix Metalloproteinases 2 and 9 in Acute Renal Pathologies. Bull Exp Biol Med 166, 334–338 (2019). https://doi.org/10.1007/s10517-019-04345-y

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  • DOI: https://doi.org/10.1007/s10517-019-04345-y

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